New Bone Research Study Results from Huaiyin Institute of Technology Described (Room-temperature attachment of PLGA microspheres to titanium surfaces for implant-based drug release)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Bone Research are presented in a new report. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "Drug release from implant surfaces is an effective approach to impart biological activities, (e.g., antimicrobial and osteogenic properties) to bone implants. Coatings of polylactide-based polymer are a candidate for this purpose, but a continuous (fully covering) coating may be non-optimal for implant-bone fixation."
Our news journalists obtained a quote from the research from the Huaiyin Institute of Technology, "This study reports a simple room-temperature method for attaching poly (lactide-co-glycolide) (PLGA) microspheres to titanium (Ti) surfaces. Microspheres were prepared with polyvinyl alcohol (PVA) or polyvinylpyrrolidone (PVP) as the emulsifier. Microspheres were attached to Ti discs by pipetting as a suspension onto the surfaces followed by vacuum drying. After immersion in shaking water bath for 14d, a substantial proportion of the microspheres remained attached to the discs. In contrast, if the vacuum-drying procedure was omitted, only a small fraction of the microspheres remained attached to the discs after immersion for only 5 min. Microspheres containing triclosan (a broad-spectrum antibiotic) were attached by porous-surfaced Ti discs. In vitro experiments showed that the microsphere-carrying discs were able to kill Staphylococcus aureus and Escherichia Coll, and support the adhesion and growth of primary rat osteoblasts."
According to the news editors, the research concluded: "This simple method may offer a flexible technique for bone implant-based drug release."
For more information on this research see: Room-temperature attachment of PLGA microspheres to titanium surfaces for implant-based drug release. Applied Surface Science, 2014;309():112-118. Applied Surface Science can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Applied Surface Science - www.elsevier.com/wps/product/cws_home/505669)
Our news journalists report that additional information may be obtained by contacting D.Q. Xiao, Huaiyin Inst Technol, Jiangsu Prov Key Lab Intervent Med Devices, Huaiyin 223001, Jiangsu, People's Republic of China. Additional authors for this research include Q. Liu, D.W. Wang, T. Xie, T.L. Guo, K. Duan and J. Weng (see also Bone Research).
Keywords for this news article include: Jiangsu, People's Republic of China, Asia, Bone Research, Light Metals, Titanium
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