By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Anions. According to news reporting out of Chengdu, People's Republic of China, by NewsRx editors, research stated, "We fabricated a magnetic calcium phosphate nanoformulation by the biomineralization of calcium phosphate on the surface of magnetic nanoparticles with abundant amino groups, and thus the inorganic layer of calcium phosphate can improve the biocompatibility and simultaneously the magnetic iron oxide can maintain the magnetic targeting function. Two types of anticancer drug models, doxorubicin hydrochloride and DNA, were entrapped in these nanocarriers, respectively."
Our news journalists obtained a quote from the research from Southwest Jiaotong University, "This delivery system displayed high pH sensitivity in drug-controlled release profile as the dissolution of CaP under acid pH condition. Magnetofection was performed to investigate the intracellular uptake and the anti-proliferative effect of tumor cells in the presence of an external magnet."
According to the news editors, the research concluded: "The transfection of the DNA-loaded magnetic system in A549 and HepG2 tumor cells demonstrated that the magnetic nanoformulation could enhance the transfection efficiency to 30% with an applied external magnetic field."
For more information on this research see: Biodegradable magnetic calcium phosphate nanoformulation for cancer therapy. European Journal of Pharmaceutics and Biopharmaceutics, 2014;87(1):90-100. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)
Our news journalists report that additional information may be obtained by contacting Z.M. Tang, Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, People's Republic of China. Additional authors for this research include Y.B. Zhou, H.L. Sun, D. Li and S.B. Zhou (see also Anions).
Keywords for this news article include: Chengdu, People's Republic of China, Asia, Anions, Calcium Compounds, Calcium Phosphates, Cancer, Inorganic Chemicals, Oncology, Phosphoric Acids, Phosphorus Compounds, Therapy
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