News Column

Investigators from Aalto University Target Pharmacokinetics (Virtual pharmacokinetic model of human eye)

July 30, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Pharmacokinetics have been published. According to news reporting from Aalto, Finland, by NewsRx journalists, research stated, "A virtual pharmacolcinetic 3D model of the human eye is built using Comsol Multiphysics software, which is based on the Finite Element Method (FEM). The model considers drug release from a polymer patch placed on sclera."

The news correspondents obtained a quote from the research from Aalto University, "The model concentrates on the posterior part of the eye, retina being the target tissue, and comprises the choroidal blood flow, partitioning of the drug between different tissues and active transport at the retina pigment epithelium (RPE) choroid boundary. Although most straightforward, in order to check the mass balance, no protein binding or metabolism is yet included. It appeared that the most important issue in obtaining reliable simulation results is the finite element mesh, while time stepping has hardly any significance. Simulations were extended to 100,000 s. The concentration of a drug is shown as a function of time at various points of retina, as well as its average value, varying several parameters in the model."

According to the news reporters, the research concluded: "This work demonstrates how anybody with basic knowledge of calculus is able to build physically meaningful models of quite complex biological systems."

For more information on this research see: Virtual pharmacokinetic model of human eye. Mathematical Biosciences, 2014;253():11-18. Mathematical Biosciences can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Mathematical Biosciences -

Our news journalists report that additional information may be obtained by contacting S. Kotha, Aalto Univ, Sch Chem Technol, Dept. of Chem, Aalto 00076, Finland (see also Pharmacokinetics).

Keywords for this news article include: Aalto, Finland, Europe, Drugs, Pharmaceuticals, Pharmacokinetics, Therapy

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Source: Biotech Week

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