Investigators at Institute for Tumor Biology Report Findings in Cancer Gene Therapy (Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: New insight into ...)
By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "MUC4/Y, the transcript variant 4 of MUC4, lacks exon 2 as compared with the transcript variant 1 of MUC4. To date, direct evidence for the function of MU4/Y remains to be reported."
Our news journalists obtained a quote from the research from Institute for Tumor Biology, "Previous studies based their hypotheses regarding the function of MUC4/Y on the characteristic structure domains of this variant. The aim of the present study was to investigate the specific function of MUC4/Y. The pancreatic cancer cell line MIA PaCa-2 with low MUC4/Y expression was used to establish a stable cell model of MUC4/Y upregulation using a lentivirus vector system. MUC4/Y anchored on the cytomembrane and affected cell morphology and cell cycle. Functional analyses indicated that MUC4/Y upregulation slightly potentiated cell proliferation and significantly suppressed apoptosis both in vivo and in vitro. Further studies revealed that the JNK and AKT signalling pathways were activated. Meanwhile, MUC4/Y upregulation elicited minimal effect on the phosphorylation level of HER2, a membrane partner of MUC4."
According to the news editors, the research concluded: "These results suggest that MUC4/Y promotes tumour progression through its antiapoptotic and weak mitogenic effect on MIA PaCa-2 cells."
For more information on this research see: Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: New insight into the presence of the transcript variant of MUC4. Oncology Reports, 2014;31(5):2187-2194. Oncology Reports can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece (see also Biotechnology).
The news correspondents report that additional information may be obtained from K.L. Xie, Inst Tumor Biol, Jiangsu Prov Academy Clin Med, Nanjing 210029, Jiangsu, People's Republic of China. Additional authors for this research include X.F. Zhi, J. Tang, Y. Zhu, J.J. Zhang, Z. Li, J.Q. Tao and Z.K. Xu.
Keywords for this news article include: Jiangsu, People's Republic of China, Asia, Apoptosis, Biotechnology, Cancer Gene Therapy, Gastroenterology, Oncology, Pancreas, Pancreatic Cancer, Pancreatic Neoplasms
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