Findings from University of Crete Provide New Insights into Toxicology (Dialkyl phosphates in amniotic fluid as a biomarker of fetal exposure to organophosphates in Crete, Greece; association with fetal growth)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Life Science Research. According to news reporting originating in Iraklion, Greece, by NewsRx journalists, research stated, "The aim of this study was to evaluate fetal exposure to organophosphate pesticides (OPs) by measuring their non-specific dialkyl-phosphate metabolites (DAPs) in amniotic fluid (AF), and to examine the potential association between prenatal exposure and fetal growth. AF samples were collected from 415 women during the second gestational trimester."
The news reporters obtained a quote from the research from the University of Crete, "The determined OPs metabolites were DMP, DMTP, DEP, DETP, and DEDTP. DAPs were extracted by liquid-solid extraction, derivatized and analyzed by gas chromatography-mass spectrometry. 97.8% of AF samples were positive for at least one DAP. DAPs levels did not differ between urban and rural areas. Macrosomic neonates have significantly higher sum levels of DMPs (p = 0.043), which exerted a linear positive association with birth-weight centile (b = 4.43, p = 0.016). Conclusively, as DAPs are detectable in AF they may be used as a potential biomarker of fetal exposure to OPs."
According to the news reporters, the research concluded: "Sum levels of DMPs appear to be associated with birth weight independently of other covariates."
For more information on this research see: Dialkyl phosphates in amniotic fluid as a biomarker of fetal exposure to organophosphates in Crete, Greece; association with fetal growth. Reproductive Toxicology, 2014;46():98-105. Reproductive Toxicology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Reproductive Toxicology - www.elsevier.com/wps/product/cws_home/525489)
Our news correspondents report that additional information may be obtained by contacting D. Koutroulakis, University of Crete, Lab Toxicol Sci & Res, Iraklion, Crete, Greece. Additional authors for this research include S. Sifakis, M.N. Tzatzarakis, A.K. Alegakis, E. Theodoropoulou, M.P. Kavvalakis, D. Kappou and A.M. Tsatsakis (see also Life Science Research).
Keywords for this news article include: Iraklion, Greece, Europe, Life Science Research
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