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Findings from University of Alabama Provides New Data about Biochemical Parasitology (Isolation and substrate specificity of an adenine nucleoside...

July 29, 2014



Findings from University of Alabama Provides New Data about Biochemical Parasitology (Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in Birmingham, Alabama, by NewsRx journalists, research stated, "An adenine nucleoside phosphorylase (ANP, EC none) activity was identified and partially purified from extracts of Schistosoma mansoni by chromatofocussing column chromatography and molecular sieving. The enzyme is distinct from purine nucleoside phosphorylase (PNP, EC 2.4.2.1)."

The news reporters obtained a quote from the research from the University of Alabama, "ANP is specific for adenine nucleosides which includes adenosine analogs modified in the aglycone, pentose or both moieties. (e.g. 2'-deoxyadenosine, 5'-deoxy-5'-methylthioadenosine, 5'-deoxy-5'-iodo-2-fluoroadenosine, etc.) The enzyme is also distinct from the mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28) in that it is able of the phosphorolysis of 2'-deoxyadenosine while mammalian MTAP cannot. Because of ANP unique substrate specificity, the enzyme could play a role as a target for chemotherapy of these parasites."

According to the news reporters, the research concluded: "Cytotoxic analogs may be designed as subversive substrates that are selectively activated only by the schistosomal ANP."

For more information on this research see: Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni. Molecular and Biochemical Parasitology, 2014;194(1-2):44-47. Molecular and Biochemical Parasitology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Molecular and Biochemical Parasitology - www.elsevier.com/wps/product/cws_home/506086)

Our news correspondents report that additional information may be obtained by contacting T.M. Savarese, Univ Alabama Birmingham, Dept. of Pharmacol & Toxicol, Birmingham, AL 35294, United States (see also Life Science Research).

Keywords for this news article include: Birmingham, Alabama, United States, North and Central America, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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