By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Light Therapy. According to news reporting originating in Durban, South Africa, by NewsRx journalists, research stated, "A method for the preparation of superparamagnetic iron oxide nanoparticle-porphyrin (SPION-TPP) conjugates through click chemistry, which can be used as novel theranostic nanoagents for photodynamic therapy is developed. The synthesis, characterisation, and evaluation of the photocytotoxicity profiles of the nanoconjugates prepared is reported."
The news reporters obtained a quote from the research from the University of KwaZulu-Natal, "Upon light irradiation, SPION-TPP nanoconstructs promote a photodynamic effect in vitro in murine amelanotic melanoma B78-H1 cells, with IC50 values in the region of 800 nm, similarly to unbound TPP, whereas they remain non-cytotoxic in the dark. However, these nanoconstructs show poor cellular uptake, which influen-ces a linear dose-response effect. Therefore, the improvement of delivery to cells has also been studied by conjugating a well-known cell-penetrating peptide (TAT peptide) to the SPION-TPP nanoparticles. The new nanoconstructs show lower IC50 values (in the region of 500 nm) and a clear dose-response effect."
According to the news reporters, the research concluded: "Our results suggest that TAT-conjugated SPION-TPP nanoparticles are efficient nanodevices both for tracking drugs by means of magnetic resonance imaging (MRI)-based techniques and for treating cancer cells through photodynamic therapy, thus functioning as promising theranostic nanoagents."
For more information on this research see: "Clicking" Porphyrins to Magnetic Nanoparticles for Photodynamic Therapy. Chempluschem, 2014;79(1):90-98. Chempluschem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Chempluschem - onlinelibrary.wiley.com/journal/10.1002/(ISSN)2192-6506)
Our news correspondents report that additional information may be obtained by contacting M. Thandu, University of KwaZulu Natal, Sch Chem & Phys, ZA-4001 Durban, South Africa. Additional authors for this research include V. Rapozzi, L. Xodo, F. Albericio, C. Comuzzi and S. Cavalli (see also Light Therapy).
Keywords for this news article include: Durban, South Africa, Africa, Biological Pigments, Biotechnology, Emerging Technologies, Light Therapy, Nanoparticle, Nanotechnology, Photodynamic Therapy, Photodynamics, Phototherapy, Porphyrins
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