Data on Arsenic Detailed by Researchers at University of Huelva (A combination of metallomics and metabolomics studies to evaluate the effects of metal interactions in mammals. Application to Mus musculus mice under arsenic/cadmium exposure)
By a News Reporter-Staff News Editor at Proteomics Weekly -- Fresh data on Arsenic are presented in a new report. According to news reporting out of Huelva, Spain, by NewsRx editors, research stated, "Arsenic and cadmium are toxic metals of environmental significance with harmful effects on man. To study the toxicological and biochemical effects of arsenic/cadmium in mammals a combined metallomic and metabolomic approach has been developed, complemented with the measurement of biochemical parameters in blood and histopathological evaluation of liver injury in mice Mus musculus under exposure to both xenobidlics."
Our news journalists obtained a quote from the research from the University of Huelva, "Size-exclusion chromatography (SEC) was combined with affinity chromatography (AF) and ICP-MS detection using species unspecific isotopic dilution analysis (SUID) to characterize the biological effects of As/Cd on selenium containingproteins in the bloodstream of exposed mice. On the other hand, both direct infusion mass spectrometry (DIMS) and gas chromatography mass spectrometry (GC MS) provided information about changes in metabolites caused by metals. The results show that As/Cd exposure produces interactions in the distribution of both toxics between organs and plasma of mice and antagonistic interactions with selenium containing proteins in the bloodstream. Interplay with essential metabolic pathways, such as energy metabolism and breakdown of membrane phospholipids were observed, which are more pronounced under As/Cd exposure. In addition, heavy metal and metalloid causes differential liver injury, manifested by steatosis (non-alcoholic fatty liver disease, NAFLD) and infiltration of blood cells into the space of Disse. Biological significance This work presents new contributions in the study of arsenic/cadmium interactions in mice Mus musculus under controlled exposure. With the combination of metallomic and metabolomic approaches the traffic of As and Cd from liver to kidney by means of blood was observed and excretion of As (as arsenic metabolites) or Cd (as MTCd) is inhibited with the simultaneous administration of As/Cd, and these toxic elements have important influence in the levels of seleno-proteins in the plasma."
According to the news editors, the research concluded: "In addition, the metabolomic approach reveals inhibition of different metabolic cycles such as tricarboxylic acid and phospholipid degradation that causes membrane damage and apoptosis that is histopathologically confirmed."
For more information on this research see: A combination of metallomics and metabolomics studies to evaluate the effects of metal interactions in mammals. Application to Mus musculus mice under arsenic/cadmium exposure. Journal of Proteomics, 2014;104():66-79. Journal of Proteomics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Proteomics - www.elsevier.com/wps/product/cws_home/713351)
Our news journalists report that additional information may be obtained by contacting M.A. Garcia-Sevillano, Univ Huelva, Fac Expt Sci, Dept. of Environm Biol & Public Hlth, Huelva 21007, Spain. Additional authors for this research include T. Garcia-Barrera, F. Navarro-Roldan, Z. Montero-Lobato and J.L. Gomez-Ariza (see also Arsenic).
Keywords for this news article include: Huelva, Spain, Europe, Arsenic, Biochemical, Biochemistry, Cadmium, Chemicals, Chemistry, Heavy Metals, Transition Elements
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