News Column

Study Results from National Research Council Broaden Understanding of Nanoparticles (Cancer-Cell-Targeted Theranostic Cubosomes)

July 8, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Nanoparticles are discussed in a new report. According to news reporting from Pisa, Italy, by NewsRx journalists, research stated, "This work was devoted to the development of a new type of lipid-based (cubosome) theranostic nanoparticle able to simultaneously host camptothecin, a potent anticancer drug, and a squarain-based NIR-emitting fluorescent probe."

The news correspondents obtained a quote from the research from National Research Council, "Furthermore, to confer targeting abilities on these nanoparticles, they were dispersed using mixtures of Pluronic F108 and folate-conjugated Pluronic F108 in appropriate ratios. The physicochemical characterization, performed via SAXS, DLS, and cryo-TEM techniques, proved that aqueous dispersions of such cubosomes can be effectively prepared, while the photophysical characterization demonstrated that these nanoparticles may be used for in vivo imaging purposes."

According to the news reporters, the research concluded: "The superior ability of these innovative nanoparticles in targeting cancer cells was emphasized by investigating the lipid droplet alterations induced in He La cells upon exposure to targeted and nontargeted cubosomes."

For more information on this research see: Cancer-Cell-Targeted Theranostic Cubosomes. Langmuir, 2014;30(21):6228-6236. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Langmuir -

Our news journalists report that additional information may be obtained by contacting C. Caltagirone, UO Pisa, CNR, Ist Biofis, I-56124 Pisa, Italy. Additional authors for this research include A.M. Falchi, S. Lampis, V. Lippolis, V. Meli, M. Monduzzi, L. Prodi, J. Schmidt, M. Sgarzi, Y. Talmon, R. Bizzarri and S. Murgia (see also Nanoparticles).

Keywords for this news article include: Pisa, Italy, Europe, Cancer, Oncology, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Weekly

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