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Study Results from J.J. Wang and Colleagues Broaden Understanding of Drug Delivery Systems (Magnetic nanoparticles with a pH-sheddable layer for...

July 9, 2014



Study Results from J.J. Wang and Colleagues Broaden Understanding of Drug Delivery Systems (Magnetic nanoparticles with a pH-sheddable layer for antitumor drug delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news reporting from Tianjin, People's Republic of China, by NewsRx journalists, research stated, "A dually responsive nanocarrier with a multilayer core shell architecture was prepared based on Fe3O4@SiO2 nanoparticles successively coated with poly(benzyl L-aspartate) (PBLA) and poly(ethylene glycol) (PEG) for the purpose of tumor specific drug delivery applications. In this system, PEG chains are connected to the surface via pH-sensitive benzoic-imine bonds and serve as a pH-sheddable hydrophilic corona."

The news correspondents obtained a quote from the research, "Meanwhile, the PBLA segments serve as a hydrophobic middle layer used to load the drugs via hydrophobic interactions. The Fe3O4@SiO2 nanoparticle functions as a superparamagnetic core used to direct the drug loaded nanocarrier to the target pathological site. The obtained materials were characterized with FT-IR, H-1 NMR, dynamic light scattering, zeta-potential, TEM, TGA, and hysteresis loop analysis. An anticancer drug doxorubicin (DOX) was selected as the model drug loaded into the nanocarrier, which was relatively stable under physiological conditions due to its neutral hydrophilic shell, and could quickly release the drug in response to increased acidity via shedding of the PEG shells through cleavage of the intermediate benzoic-imine bonds. Meanwhile, the neutral shell shedding would reveal a positively charged nanoparticle surface that is readily taken up by tumor cells."

According to the news reporters, the research concluded: "These pH- and magnetic-responsive nanoparticles showed significant potential for use in the targeted intracellular delivery of hydrophobic chemotherapeutics in cancer therapy."

For more information on this research see: Magnetic nanoparticles with a pH-sheddable layer for antitumor drug delivery. Colloids and Surfaces B-Biointerfaces, 2014;118():218-225. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting J.J. Wang, Collaborat Innovat Center Chem Sci & Engn, Tianjin, People's Republic of China. Additional authors for this research include C. Gong, Y.N. Wang and G.L. Wu.

Keywords for this news article include: Asia, Tianjin, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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