Studies from Tarbiat Modares University Further Understanding of Cancer Therapy (Electrochemically controlled release of anticancer drug methotrexate using nanostructured polypyrrole modified with cetylpyridinium: Release kinetics investigation)
By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Oncology have been presented. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "A new simple strategy for direct electrochemical incorporation of chemotherapeutic methotrexate (MTX) into conductive polypyrrole (PPy) has been suggested for an electrochemically controlled loading and release system. Electropolymerization of MTX doped polypyrrole yielded poor quality with low efficiency of doping, but a well-doped, nanostructure and increased capacity of drug loading (24.5 mg g(-1)) has been obtained in the presence of cetylpyridinium (CP) as a modifier."
The news reporters obtained a quote from the research from Tarbiat Modares University, "When CP was preloaded onto PPy, the hydrophobic surface of the PPy serves as a backbone to which the hydrophobic chain of the CP can be attached. Electrostatic interaction between cationic CP with anionic MIX and aromatic interaction between pyridinium head of CP with pyrimidine and pyrazine rings of MIX increases drug doping. Then release kinetics were investigated at various applied potentials and temperatures. Kinetics analysis based on Avrami's equation showed that the drug release was controlled and accelerated by increasing temperature and negative potential and sustained by increasing positive potential. At open circuit condition, the release parameter (n) represented a diffusive mechanism and at applying electrochemical potentials, a first-order mode. Activation energy parameters (E-a, Delta G(not equal), Delta H-not equal and Delta S-not equal ) and half-life time (t(1/2)) of drug release are also analyzed as a function of applied potential. The nanostructured polymer films (PPy/CP/MTX) were characterized by several techniques: scanning electron microscopy, Furrier transforms Infrared, UV-vis spectroscopy."
According to the news reporters, the research concluded: "Overall, our results demonstrate that the PPy/CP/MTX films, combined with electrical stimulation, permit a programmable release of MIX by altering the interaction strength between the PPy/CP and MIX."
For more information on this research see: Electrochemically controlled release of anticancer drug methotrexate using nanostructured polypyrrole modified with cetylpyridinium: Release kinetics investigation. Electrochimica Acta, 2014;130():488-496. Electrochimica Acta can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England (see also Oncology).
Our news correspondents report that additional information may be obtained by contacting N. Alizadeh, Tarbiat Modares Univ, Fac Sci, Dept. of Chem, Tehran, Iran.
Keywords for this news article include: Iran, Asia, Tehran, Therapy, Oncology, Chemistry, Electrochemical, Controlled Release
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