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Studies from Sichuan University Reveal New Findings on Biointerface Research (Different effects of a novel CaO-MgO-SiO?-based multiphase...

July 8, 2014



Studies from Sichuan University Reveal New Findings on Biointerface Research (Different effects of a novel CaO-MgO-SiO?-based multiphase glass-ceramic on cell behaviors of normal and cancer cells in vitro)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Biotechnology have been published. According to news reporting originating from Chengdu, People's Republic of China, by NewsRx correspondents, research stated, "The effects in vitro of a novel multiphase glass-ceramic (with nominal composition of 43.19% CaO, 7.68% MgO, and 49.13% SiO2 in weight percent) on cell adhesion, proliferation, differentiation and ultrastructure of human osteosarcoma cell line MG63, mouse fibroblasts L929, and human lung adenocarcinoma epithelial cell line A549 were investigated in this research. Scanning electron microscopy (SEM) micrographs revealed that the surface morphology of this glass-ceramic was beneficial to cell adhesion."

Our news editors obtained a quote from the research from Sichuan University, "The glass-ceramic extracts at certain concentrations could stimulate the proliferation and differentiation of MG63 and L929 cells, whereas inhibit A549 proliferation, which might be resulted from the released Si ions. In addition, when cultured with 0.1mg/mL glass-ceramic powder suspension, the cell ultrastructure of MG63 showed abundant organelles and L929 displayed the phenomena of cellular stress response. While more interestingly, A549 exhibited chromatin condensation, mitochondria swell and RER expansion, which was presumed to be early signs of apoptosis."

According to the news editors, the research concluded: "These results suggest that this novel CaO-MgO-SiO2-based multiphase glass-ceramic has potential for bone regeneration and tissue engineering applications."

For more information on this research see: Different effects of a novel CaO-MgO-SiO?-based multiphase glass-ceramic on cell behaviors of normal and cancer cells in vitro. Colloids and Surfaces B, Biointerfaces, 2014;116():1-8 (see also Biotechnology).

The news editors report that additional information may be obtained by contacting M. Zhang, College of Materials Science and Engineering, Sichuan University, Chengdu 610064, People's Republic of China. Additional authors for this research include X. Chen, X. Pu, X. Liao, Z. Huang and G. Yin.

Keywords for this news article include: Asia, Biotechnology, Cancer, Chengdu, Oncology, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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