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Studies from Industrial Technology Research Institute Further Understanding of Toxicology (Development and Validation of an HPLC Method for...

July 8, 2014



Studies from Industrial Technology Research Institute Further Understanding of Toxicology (Development and Validation of an HPLC Method for Determination of Amikacin in Water Samples by Solid Phase Extraction and Pre-column Derivatization)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "This work presents a rapid and sensitive high performance liquid chromatography method for the determination of amikacin in water samples with solid phase extraction and pre-column derivatization. Amikacin residue was extracted from water samples with solid phase extraction cartridge."

Our news journalists obtained a quote from the research from Industrial Technology Research Institute, "Then the extraction solution was derivatized with 4-chloro-3,5-dinitrobenzotrifluoride in the presence of triethylamine at 70A degrees C in 20 min. The amikacin derivative was separated on a C-18 column and detected by application of UV detection at 238 nm. The limit of detection is 0.2 mu g/L with a signal-to-noise ratio of 3 and linearity is established over the concentration range from 0 to 500.0 mu g/L."

According to the news editors, the research concluded: "Recoveries of the amikacin in three types of water samples are from 87.5 % to 99.6 % and RSDs are 2.1 %-4.5 %. This method can be used for the quantification of amikacin residues in water samples."

For more information on this research see: Development and Validation of an HPLC Method for Determination of Amikacin in Water Samples by Solid Phase Extraction and Pre-column Derivatization. Bulletin of Environmental Contamination and Toxicology, 2014;93(1):47-52. Bulletin of Environmental Contamination and Toxicology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Bulletin of Environmental Contamination and Toxicology - www.springerlink.com/content/0007-4861/)

The news correspondents report that additional information may be obtained from D.G. Li, Beijing Ind Technol Res Inst, Beijing, People's Republic of China. Additional authors for this research include S. He, Y.F. Deng, G.L. Ding, H.W. Ni and Y.S. Cao (see also Life Science Research).

Keywords for this news article include: Asia, Beijing, Life Science Research, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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