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Studies from Goethe-University Update Current Data on Molecular Motors (ATP synthases from archaea: The beauty of a molecular motor)

July 8, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Molecular Motors is now available. According to news reporting originating in Frankfurt, Germany, by NewsRx journalists, research stated, "Archaea live under different environmental conditions, such as high salinity, extreme pHs and cold or hot temperatures. How energy is conserved under such harsh environmental conditions is a major question in cellular bioenergetics of archaea."

The news reporters obtained a quote from the research from Goethe-University, "The key enzymes in energy conservation are the archaeal A(1)A(o) ATP synthases, a class of ATP synthases distinct from the F1Eo ATP synthase ATP synthase found in bacteria, mitochondria and chloroplasts and the V1Vo ATPases of eukaiyotes. A(1)A(o) ATP synthases have distinct structural features such as a collar-like structure, an extended central stalk, and two peripheral stalks possibly stabilizing the A(1)A(o) ATP synthase during rotation in ATP synthesis/hydrolysis at high temperatures as well as to provide the storage of transient elastic energy during ion-pumping and ATP synthesis/-hydrolysis. High resolution structures of individual subunits and subcomplexes have been obtained in recent years that shed new light on the function and mechanism of this unique class of ATP synthases. An outstanding feature of archaeal A(1)A(o) ATP synthases is their diversity in size of rotor subunits and the coupling ion used for ATP synthesis with H+, Na+ or even H+ and Na+ using enzymes."

According to the news reporters, the research concluded: "The evolution of the H+ binding site to a Na+ binding site and its implications for the energy metabolism and physiology of the cell are discussed."

For more information on this research see: ATP synthases from archaea: The beauty of a molecular motor. Biochimica Et Biophysica Acta-Bioenergetics, 2014;1837(6):940-952. Biochimica Et Biophysica Acta-Bioenergetics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Molecular Motors).

Our news correspondents report that additional information may be obtained by contacting G. Gruber, Goethe Univ Frankfurt, Inst Mol Biosci, D-60438 Frankfurt, Germany. Additional authors for this research include M.S.S. Manimekalai, F. Mayer and V. Muller.

Keywords for this news article include: Europe, Germany, Synthase, Frankfurt, Nanotechnology, Molecular Motors, Emerging Technologies, Enzymes and Coenzymes

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Source: Life Science Weekly

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