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Researchers at University of Maryland School of Medicine Target Glutamate Receptors (Nanoscale scaffolding domains within the postsynaptic density...

July 7, 2014



Researchers at University of Maryland School of Medicine Target Glutamate Receptors (Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors)

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Data detailed on Membrane Proteins have been presented. According to news reporting out of Baltimore, Maryland, by NewsRx editors, research stated, "Scaffolding molecules at the postsynaptic membrane form the foundation of excitatory synaptic transmission by establishing the architecture of the postsynaptic density (PSD), but the small size of the synapse has precluded measurement of PSD organization in live cells. We measured the internal structure of the PSD in live neurons at approximately 25 nm resolution using photoactivated localization microscopy (PALM)."

Our news journalists obtained a quote from the research from the University of Maryland School of Medicine, "We found that four major PSD scaffold proteins were each organized in distinctive ?80 nm ensembles able to undergo striking changes over time. Bidirectional PALM and single-molecule immunolabeling showed that dense nanodomains of PSD-95 were preferentially enriched in AMPA receptors more than NMDA receptors. Chronic suppression of activity triggered changes in PSD interior architecture that may help amplify synaptic plasticity."

According to the news editors, the research concluded: "The observed clustered architecture of the PSD controlled the amplitude and variance of simulated postsynaptic currents, suggesting several ways in which PSD interior organization may regulate the strength and plasticity of neurotransmission."

For more information on this research see: Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron, 2013;78(4):615-22. (Elsevier - www.elsevier.com; Neuron - www.elsevier.com/wps/product/cws_home/621183)

Our news journalists report that additional information may be obtained by contacting H.D. MacGillavry, Dept. of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, United States. Additional authors for this research include Y. Song, S. Raghavachari and T.A Blanpied (see also Membrane Proteins).

Keywords for this news article include: Maryland, Baltimore, Nanoscale, United States, AMPA Receptors, Nanotechnology, Membrane Proteins, Glutamate Receptors, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Pain & Central Nervous System Week


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