Researchers at University of Maine Release New Data on Nanotechnology (Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin)
By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Nanotechnology are discussed in a new report. According to news reporting out of Orono, Maine, by NewsRx editors, research stated, "The influenza viral membrane protein hemagglutinin (HA) is required at high concentrations on virion and host-cell membranes for infectivity. Because the role of actin in membrane organization is not completely understood, we quantified the relationship between HA and host-cell actin at the nanoscale."
Our news journalists obtained a quote from the research from the University of Maine, "Results obtained using superresolution fluorescence photoactivation localization microscopy (FPALM) in nonpolarized cells show that HA clusters colocalize with actin-rich membrane regions (ARMRs). Individual molecular trajectories in live cells indicate restricted HA mobility in ARMRs, and actin disruption caused specific changes to HA clustering. Surprisingly, the actin-binding protein cofilin was excluded from some regions within several hundred nanometers of HA clusters, suggesting that HA clusters or adjacent proteins within the same clusters influence local actin structure."
According to the news editors, the research concluded: "Thus, with the use of imaging, we demonstrate a dynamic relationship between glycoprotein membrane organization and the actin cytoskeleton at the nanoscale."
For more information on this research see: Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin. Biophysical Journal, 2013;104(10):2182-92. (Elsevier - www.elsevier.com; Biophysical Journal - www.elsevier.com/wps/product/cws_home/716950)
Our news journalists report that additional information may be obtained by contacting M.V. Gudheti, Dept. of Physics and Astronomy, University of Maine, Orono, ME, United States. Additional authors for this research include N.M. Curthoys, T.J. Gould, D. Kim, M.S. Gunewardene, K.A. Gabor, J.A. Gosse, C.H. Kim, J. Zimmerberg and S.T Hess (see also Nanotechnology).
Keywords for this news article include: Orono, Maine, Nanoscale, United States, Nanotechnology, Emerging Technologies, North and Central America.
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