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Researchers at Northwestern University Detail Findings in Green Fluorescent Protein (Multimodal photoacoustic ophthalmoscopy in mouse)

July 9, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Proteins. According to news originating from Evanston, Illinois, by NewsRx correspondents, research stated, "Photoacoustic ophthalmoscopy (PAOM) is a novel imaging technology that measures optical absorption in the retina. The capability of PAOM can be further enhanced if it could image mouse eyes, because mouse models are widely used for various retinal diseases."

Our news journalists obtained a quote from the research from Northwestern University, "The challenges in achieving high-quality imaging of mouse retina, however, come from the much smaller eyeball size. Here, we report an optimized imaging system, which integrates PAOM, spectral-domain optical coherence tomography (SD-OCT), and autofluorescence-scanning laser ophthalmoscopy (AF-SLO), for mouse eyes. Its multimodal capability was demonstrated by imaging transgenic Nrl-GFP mice that express green fluorescent protein (GFP) in photoreceptors. SD-OCT provided guidance of optical alignment for PAOM and AF-SLO, and complementary contrast with high depth-resolution retinal cross sections. PAOM visualized the retinal vasculature and retinal pigment epithelium melanin, and AF-SLO measured GFP-expressing in retinal photoreceptors."

According to the news editors, the research concluded: "The in vivo imaging results were verified by histology and confocal microscopy."

For more information on this research see: Multimodal photoacoustic ophthalmoscopy in mouse. Journal of Biophotonics, 2013;6(6-7):505-12. (Wiley-Blackwell -; Journal of Biophotonics -

The news correspondents report that additional information may be obtained from W. Song, Dept. of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd, Evanston IL 60208, United States. Additional authors for this research include Q. Wei, L. Feng, V. Sarthy, S. Jiao, X. Liu and H.F Zhang (see also Proteins).

Keywords for this news article include: Evanston, Illinois, United States, North and Central America, Green Fluorescent Protein.

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Source: Biotech Week

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