Reports Summarize Cellular Structures Study Results from Nankai University (Lead sulfide nanoparticles increase cell wall chitin content and induce apoptosis in Saccharomyces cerevisiae)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Cellular Structures. According to news originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "Although there have been numerous studies on bacterial toxicity, the cytotoxicity of nanoparticles toward fungi remains poorly understood. We investigated the toxicity of various sizes of lead sulfide particles against the important model fungus, Saccharomyces cerevisiae."
Our news journalists obtained a quote from the research from Nankai University, "The smallest particle exerted the highest toxicity, inhibiting cell growth and decreasing cell viability, likely reflecting reduced sedimentation and persistent cell wall attack. In response to cell wall stress, S. cerevisiae showed an increase in the cell wall chitin content and the overexpression of FKS2 and PRM5, two genes of the cell wall integrity signaling pathway. Cell wall stress increased the concentration of intracellular reactive oxygen species, leading to mitochondrial dysfunction and cell apoptosis. The contribution of dissolved lead ions to the overall toxicity was negligible."
According to the news editors, the research concluded: "These findings provide the first demonstration of the physiological protective response of a fungus toward nanoparticles, thereby contributing useful information to the assessment of the environmental impact of metal nanoparticles."
For more information on this research see: Lead sulfide nanoparticles increase cell wall chitin content and induce apoptosis in Saccharomyces cerevisiae. Journal of Hazardous Materials, 2014;273():7-16. Journal of Hazardous Materials can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Hazardous Materials - www.elsevier.com/wps/product/cws_home/502691)
The news correspondents report that additional information may be obtained from M.Q. Sun, Nankai Univ, Affiliated High Sch, Tianjin 300071, People's Republic of China. Additional authors for this research include Q.L. Yu, M.Y. Hu, Z.W. Hao, C.D. Zhang and M.C. Li (see also Cellular Structures).
Keywords for this news article include: Asia, Tianjin, Cell Wall, Nanoparticle, Life Sciences, Nanotechnology, Saccharomycetales, Saccharomycetaceae, Cellular Structures, Emerging Technologies, Saccharomyces cerevisiae, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC