Reports on Clinical Trials and Studies Findings from University of North Carolina Provide New Insights (Pilot study for compact microbeam radiation therapy using a carbon nanotube field emission micro-CT scanner)
By a News Reporter-Staff News Editor at Clinical Trials Week -- A new study on Clinical Research is now available. According to news reporting originating in Chapel Hill, North Carolina, by NewsRx journalists, research stated, "Microbeam radiation therapy (MRT) is defined as the use of parallel, microplanar x-ray beams with an energy spectrum between 50 and 300 keV for cancer treatment and brain radiosurgery. Up until now, the possibilities of MRT have mainly been studied using synchrotron sources due to their high flux (100s Gy/s) and approximately parallel x-ray paths."
The news reporters obtained a quote from the research from the University of North Carolina, "The authors have proposed a compact x-ray based MRT system capable of delivering MRT dose distributions at a high dose rate. This system would employ carbon nanotube (CNT) field emission technology to create an x-ray source array that surrounds the target of irradiation. Using such a geometry, multiple collimators would shape the irradiation from this array into multiple microbeams that would then overlap or interlace in the target region. This pilot study demonstrates the feasibility of attaining a high dose rate and parallel microbeam beams using such a system. The microbeam dose distribution was generated by our CNT micro-CT scanner (100 mu m focal spot) and a custom-made microbeam collimator. An alignment assembly was fabricated and attached to the scanner in order to collimate and superimpose beams coming from different gantry positions. The MRT dose distribution was measured using two orthogonal radiochromic films embedded inside a cylindrical phantom. This target was irradiated with microbeams incident from 44 different gantry angles to simulate an array of x-ray sources as in the proposed compact CNT-based MRT system. Finally, phantom translation in a direction perpendicular to the microplanar beams was used to simulate the use of multiple parallel microbeams. Microbeams delivered from 44 gantry angles were superimposed to form a singlemicrobeam dose distribution in the phantom with a FWHM of 300 mu m (calculated value was 290 mu m). Also, during the multiple beam simulation, a peak to valley dose ratio of similar to 10 was found when the phantom translation distance was roughly 4x the beam width. The first prototype CNT-based x-ray tube dedicated to the development of compact MRT technology development was proposed and planned based on the preliminary experimental results presented here and the previous corresponding Monte Carlo simulations. The authors have demonstrated the feasibility of creating microbeam dose distributions at a high dose rate using a proposed compact MRT system."
According to the news reporters, the research concluded: "The flexibility of CNT field emission x-ray sources could possibly bring compact and low cost MRT devices to the larger research community and assist in the translational research of this promising new approach to radiation therapy."
For more information on this research see: Pilot study for compact microbeam radiation therapy using a carbon nanotube field emission micro-CT scanner. Medical Physics, 2014;41(6):127-136. Medical Physics can be contacted at: Amer Assoc Physicists Medicine Amer Inst Physics, Ste 1 No 1, 2 Huntington Quadrangle, Melville, NY 11747-4502, USA. (American Association of Physicists in Medicine - www.aapm.org; Medical Physics - online.medphys.org/)
Our news correspondents report that additional information may be obtained by contacting M. Hadsell, University of North Carolina, Dept. of Radiat Oncol, Chapel Hill, NC 27599, United States. Additional authors for this research include G.H. Cao, J. Zhang, L. Burk, T. Schreiber, E. Schreiber, S. Chang, J.P. Lu and O. Zhou (see also Clinical Research).
Keywords for this news article include: Fullerenes, Technology, Chapel Hill, United States, North Carolina, Carbon Nanotubes, Clinical Research, Radiation Therapy, North and Central America, Clinical Trials and Studies
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