News Column

Report Summarizes Nanotechnology Study Findings from Yonsei University (Dissolution and oral absorption of pranlukast nanosuspensions stabilized by...

July 8, 2014



Report Summarizes Nanotechnology Study Findings from Yonsei University (Dissolution and oral absorption of pranlukast nanosuspensions stabilized by hydroxypropylmethyl cellulose)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Nanotechnology. According to news reporting from Inchon, South Korea, by NewsRx journalists, research stated, "The objective of this study was to investigate the effect of particle size on the dissolution and oral absorption of pranlukast microsuspensions and nanosuspensions stabilized by hydroxypropylmethyl cellulose. Four pranlukast suspensions with different mean particle sizes (0.16, 0.89, 3.13, and 18.21 mu m) were prepared by various top-down processes such as jet milling, high pressure homogenization, and bead milling."

The news correspondents obtained a quote from the research from Yonsei University, "The dissolution rate and oral absorption of pranlukast suspensions were significantly affected by the particle size. The in vivo pharmacokinetic parameters of pranlukast suspensions were increased with decreasing mean particle size of suspensions."

According to the news reporters, the research concluded: "Especially, the AUC(0 ? 24h) and C-max values of pranlukast nanosuspension with a particle size of 0.16 mu m were approximately 3.5- and 6.3-fold greater, respectively, than that of pranlukast microsuspension with a particle size of 18.21 mu m. Therefore, the preliminary results from our study suggest that a pranlukast nanosuspension with a mean particle size of about 0.16 mu m may have significant potential for clinical application."

For more information on this research see: Dissolution and oral absorption of pranlukast nanosuspensions stabilized by hydroxypropylmethyl cellulose. International Journal of Biological Macromolecules, 2014;67():53-57. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)

Our news journalists report that additional information may be obtained by contacting I.H. Baek, Yonsei University, Coll Pharm, Inchon 406840, South Korea. Additional authors for this research include J.S. Kim, E.S. Ha, G.H. Choo, W. Cho, S.J. Hwang and M.S. Kim (see also Nanotechnology).

Keywords for this news article include: Asia, Inchon, South Korea, Nanosuspension, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Life Science Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters