Recent Studies from University of Halle-Wittenberg Add New Data to Zinc Compounds [In vitro cytotoxic effects of modified zinc oxide quantum dots on breast cancer cell lines (MCF7), colon cancer cell lines (HT29) and various fungi]
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Zinc Compounds. According to news reporting from Halle, Germany, by NewsRx journalists, research stated, "An important ideal objective of this study was to perform surface functionalization of fine (1-3 nm) ZnO quantum dot nanoparticles (QD NPs) in order to inhibit decomposition and agglomeration of nanoparticles in aqueous media. Polymers, oily herbal fatty acids, PEG (polyethylene glycol), and organosilanes are the main reagents used in these reactions, because they are completely soluble in water, and can be used as biological probes in nanomedicine."
The news correspondents obtained a quote from the research from the University of Halle-Wittenberg, "Vegetable fatty acid-capped ZnO (QD NPs) was fabricated by dissolving at a suitable pH after sol-gel method in the presence of nonionic surfactants as efficient templates with a particular HLB (hydrophilic-lipophilic balance) value (9.7 and 8.2). In the present research, we focused on the cellular toxicity of fine zinc oxide QD NPs containing particular blue fluorescence for targeted delivery of MCF7 and HT29 cancer cell lines. The IC50 values were determined as 10.66 and 5.75 A mu g/ml for MCF7 and HT29, respectively. These findings showed that ZnO QDs have low toxicity in normal cells (MDBK) and can display potential application in cancer chemotherapy in the near future. These properties could result in the generation of a promising candidate in the field of nanobiomedicine."
According to the news reporters, the research concluded: "The robust-engineered ZnO QD NPs showed their antibacterial and antifungal activities against Bacillus anthracis, Staphylococcus aureus, Klebsiella pneumonia, and Staphylococcus epidermidis bacteria and also different fungi such as Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes, Candida albicans, and Candida tropicalis, compared with the standard antibiotic agents like Gentamicin and Clotrimazol."
For more information on this research see: In vitro cytotoxic effects of modified zinc oxide quantum dots on breast cancer cell lines (MCF7), colon cancer cell lines (HT29) and various fungi. Journal of Nanoparticle Research, 2014;16(7):1-14. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news journalists report that additional information may be obtained by contacting Z. Fakhroueian, University of Halle Wittenberg, Inst Pharm, Biomed Mat Grp, Halle, Germany. Additional authors for this research include A.M. Dehshiri, F. Katouzian and P. Esmaeilzadeh (see also Zinc Compounds).
Keywords for this news article include: Halle, Europe, Germany, Chemicals, Chemistry, Zinc Oxide, Nanoparticle, Quantum Dots, Nanotechnology, Zinc Compounds, Quantum Physics, Emerging Technologies
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