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Recent Findings in DNA Vaccines Described by Researchers from Atomic Energy Commission (A DNA vaccine encoding p39 and sp41 of Brucella melitensis...

July 9, 2014



Recent Findings in DNA Vaccines Described by Researchers from Atomic Energy Commission (A DNA vaccine encoding p39 and sp41 of Brucella melitensis induces protective immunity in BALB/c mice)

By a News Reporter-Staff News Editor at Vaccine Weekly -- Fresh data on Biotechnology are presented in a new report. According to news reporting originating from Damascus, Syria, by NewsRx correspondents, research stated, "Brucella species are facultative intracellular gram-negative bacteria that can multiply within phagocytic and non-phagocytic cells of humans or animals as end hosts. B. melitensis causes abortion in pregnant animals and undulant fever in humans. A 41 kDa surface protein (sp41) is associated with bacterial adherence and invasion of HeLa cells."

Our news editors obtained a quote from the research from Atomic Energy Commission, "The role of this protein a is important for the interaction with host cells. Previously, the putative periplasmic binding protein p39 had been described as T-cell immunodominant Brucella antigens. Both vectors (pCIp39 and pCIsp41) induced antigen-specific serum immunoglobulin as well as a T-cell-proliferative response and a strong gamma interferon production upon re-stimulation with either the specific antigens or Brucella extract."

According to the news editors, the research concluded: "The level of protection was significant in pCIp39 and pCIsp41 treated mice but it was lower than the required level."

For more information on this research see: A DNA vaccine encoding p39 and sp41 of Brucella melitensis induces protective immunity in BALB/c mice. Archivos De Medicina Veterinaria, 2014;46(1):53-62. Archivos De Medicina Veterinaria can be contacted at: Univ Austral Chile, Fac Ciencias Veterinarias, Casilla 567, Valdivia, 00000, Chile (see also Biotechnology).

The news editors report that additional information may be obtained by contacting A. Al-Mariri, Atom Energy Commiss, Dept. of Mol Biol & Biotechnol, Damascus, Syria. Additional authors for this research include R. Akel and A.Q. Abbady.

Keywords for this news article include: Asia, Biotechnology, Syria, Damascus, DNA Vaccines, Synthetic Vaccines, Biological Products

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Vaccine Weekly


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