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Recent Findings from Central South University Has Provided New Information about Immunoglobulins (BRCAA1 antibody- and Her2 antibody-conjugated...

July 8, 2014



Recent Findings from Central South University Has Provided New Information about Immunoglobulins (BRCAA1 antibody- and Her2 antibody-conjugated amphiphilic polymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Immunology have been published. According to news reporting from Changsha, People's Republic of China, by NewsRx journalists, research stated, "Successful development of safe and highly effective nanoprobes for targeted imaging of in vivo early gastric cancer is a great challenge. Herein, we choose the CdSe/ZnS (core-shell) quantum dots (QDs) as prototypical materials, synthesized one kind of a new amphiphilic polymer including dentate-like alkyl chains and multiple carboxyl groups, and then used the prepared amphiphilic polymer to modify QDs."

The news correspondents obtained a quote from the research from Central South University, "The resultant amphiphilic polymer engineered QDs (PQDs) were conjugated with BRCAA1 and Her2 monoclonal antibody, and prepared BRCAA1 antibody- and Her2 antibody-conjugated QDs were used for in vitro MGC803 cell labeling and in vivo targeted imaging of gastric cancer cells. Results showed that the PQDs exhibited good water solubility, strong photoluminescence (PL) intensity, and good biocompatibility. BRCAA1 antibody- and Her2 antibody-conjugated QD nanoprobes successfully realized targeted imaging of in vivo gastric cancer MGC803 cells."

According to the news reporters, the research concluded: "BRCAA1 antibody- and Her2 antibody-conjugated PQDs have great potential in applications such as single cell labeling and in vivo tracking, and targeted imaging and therapeutic effects' evaluation of in vivo early gastric cancer cells in the near future."

For more information on this research see: BRCAA1 antibody- and Her2 antibody-conjugated amphiphilic polymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer. Nanoscale Research Letters, 2014;9():1-13. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Nanoscale Research Letters - www.springerlink.com/content/1931-7573/)

Our news journalists report that additional information may be obtained by contacting C. Li, Central South University, Xiangyan Hosp, Dept. of Orthoped, Changsha 410008, Hunan, People's Republic of China. Additional authors for this research include Y. Ji, C. Wang, S.J. Liang, F. Pan, C.L. Zhang, F. Chen, H.L. Fu, K. Wang and D.X. Cui (see also Immunology).

Keywords for this news article include: Asia, Antibodies, Cancer, Changsha, Oncology, Immunology, Engineering, Quantum Dots, Blood Proteins, Nanotechnology, Immunoglobulins, Quantum Physics, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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