News Column

Patent Issued for Laminate Sheet Articles for Tissue Regeneration

July 9, 2014



By a News Reporter-Staff News Editor at Biotech Week -- A patent by the inventor Matheny, Robert G. (Norcross, GA), filed on February 23, 2011, was published online on June 24, 2014, according to news reporting originating from Alexandria, Virginia, by NewsRx correspondents (see also CorMatrix Cardiovascular, Inc.).

Patent number 8758448 is assigned to CorMatrix Cardiovascular, Inc. (Roswell, GA).

The following quote was obtained by the news editors from the background information supplied by the inventors: "Tissue regeneration has been accomplished by using extracellular matrix material derived from mammalian tissues. Some of these mammalian tissues that have been described in patent literature include small intestine submucosa (SIS), liver basement membrane (LBM), urinary bladder submucosa (UBS) and stomach submucosa (SS). See U.S. Pat. Nos. 5,554,389, 4,902,508, and 5,281,422. Enamel matrices, which are the extracellular matrix around forming teeth, are described in U.S. Pat. No. 7,033,611. Extracellular matrices from these tissues have been isolated and dried to become solid materials (sheets and particulates). Particulate forms can be rehydrated in a suitable buffer to become fluidized or emulsive forms. Presently, these extracellular matrix compositions are used for tissue grafting, wound healing, and tissue regenerative purposes. (cite WSJ article)

"It would be advantageous to the field of tissue engineering to invent articles and compositions for effecting improved tissue regeneration."

In addition to the background information obtained for this patent, NewsRx journalists also obtained the inventor's summary information for this patent: "The invention is an article for wound healing and tissue regeneration comprising two or more sheets of mammalian extracellular matrix, said sheets of mammalian extracellular matrix laminated to each other to form a planar laminated article of mammalian extracellular matrix.

"The invention is an article for wound healing and tissue regeneration comprising two or more sheets of mammalian extracellular matrix, said sheets of mammalian extracellular matrix laminated to each other to form a planar laminated article of mammalian extracellular matrix, said article further comprising in between at least two of said sheets at least one cell to further effect wound healing or tissue regeneration upon placement of said laminated article in a mammal at a site in said mammal in need of wound healing or tissue regeneration.

"In the article the cell can be a stem cell. The cell can be a mesechymal cell.

"The invention is also a method comprising: identifying a defect or wound in mammalian tissue which could benefit from tissue regeneration or wound healing, providing an article comprising two or more sheets of mammalian extracellular matrix, said sheets of mammalian extracellular matrix laminated to each other to form a planar laminated article of mammalian extracellular matrix, contacting said defect or wound with said article, and regenerating tissue at said defect or healing said wound thereby."

URL and more information on this patent, see: Matheny, Robert G.. Laminate Sheet Articles for Tissue Regeneration. U.S. Patent Number 8758448, filed February 23, 2011, and published online on June 24, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8758448.PN.&OS=PN/8758448RS=PN/8758448

Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Cardiology, Bioengineering, Cardiovascular, Extracellular Space, Tissue Regeneration, Extracellular Matrix.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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