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New Oligopeptides Study Findings Have Been Reported by Researchers at University of Aveiro [Brain glutathione redox system significance for the...

July 8, 2014



New Oligopeptides Study Findings Have Been Reported by Researchers at University of Aveiro [Brain glutathione redox system significance for the control of silica-coated magnetite nanoparticles with or without mercury co-exposures mediated ...]

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Peptides. According to news originating from Aveiro, Portugal, by NewsRx correspondents, research stated, "This in vitro study investigates the impact of silicacoated magnetite particles (Fe3O4@SiO2/SiDTC, hereafter called IONP; 2.5 mg L-1) and its interference with coexposure to persistent contaminant (mercury, Hg; 50 mu g L-1) during 0, 2, 4, 8, 16, 24, 48, and 72 h on European eel (Anguilla anguilla) brain and evaluates the significance of the glutathione (GSH) redox system in this context. The extent of damage (membrane lipid peroxidation, measured as thiobarbituric acid reactive substances, TBARS; protein oxidation, measured as reactive carbonyls, RCs) decreased with increasing period of exposure to IONP or IONP + Hg which was accompanied with differential responses of glutathione redox system major components (glutathione reductase, GR; glutathione peroxidase, GPX; total GSH, TGSH)."

Our news journalists obtained a quote from the research from the University of Aveiro, "The occurrence of antagonism between IONP and Hg impacts was evident at late hour (72 h), where significantly decreased TBARS and RC levels and GR and glutathione sulfotransferase (GST) activity imply the positive effect of IONP + Hg concomitant exposure against Hg-accrued negative impacts [vs. early (2 h) hour of exposure]. A period of exposuredependent IONP alone and IONP + Hg joint exposureaccrued impact was perceptible. Additionally, increased susceptibility of the GSH redox system to increased period of exposure to Hg was depicted, where insufficiency of elevated GR for the maintenance of TGSH required for membrane lipid and cellular protein protection was displayed."

According to the news editors, the research concluded: "Overall, a finetuning among brain glutathione redox system components was revealed controlling IONP + Hg interactive impacts successfully."

For more information on this research see: Brain glutathione redox system significance for the control of silica-coated magnetite nanoparticles with or without mercury co-exposures mediated oxidative stress in European eel (Anguilla anguilla L.). Environmental Science and Pollution Research, 2014;21(12):7746-7756. Environmental Science and Pollution Research can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Environmental Science and Pollution Research - www.springerlink.com/content/0944-1344/)

The news correspondents report that additional information may be obtained from N.A. Anjum, University of Aveiro, Dept. of Biol, Center Environm & Marine Studies CESAM, P-3810193 Aveiro, Portugal. Additional authors for this research include K. Srikanth, I. Mohmood, I. Sayeed, T. Trindade, A.C. Duarte, E. Pereira and I. Ahmad (see also Peptides).

Keywords for this news article include: Aveiro, Europe, Portugal, Glutathione, Nanoparticle, Oligopeptides, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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