New Nanoparticles Study Findings Have Been Reported from Jiangnan University (Functionalized Mesoporous Silica Nanoparticles with Mucoadhesive and Sustained Drug Release Properties for Potential Bladder Cancer Therapy)
By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Nanoparticles. According to news reporting out of Wuxi, People's Republic of China, by NewsRx editors, research stated, "The synthesis of a series of beta-cyclodextrin modified mesoporous silica nanoparticles with hydroxyl, amino, and thiol groups was described. A comparison of their mucoadhesive properties and potential as a drug delivery system for superficial bladder cancer therapy was made."
Our news journalists obtained a quote from the research from Jiangnan University, "The thiol-functionalized nanoparticles exhibit significantly higher mucoadhesivity on the urothelium as compared to the hydroxyl- and amino-functionalized nanoparticles. This is attributed to the formation of disulfide bonds between the thiol-functionalized nanoparticles and cysteine-rich subdomains of mucus glycoproteins. An anticancer drug, doxorubicin, was loaded into the mesopores of the thiol-functionalized nanoparticles, and sustained drug release triggered by acidic pH was achieved."
According to the news editors, the research concluded: "The present study demonstrates that thiol-functionalized mesoporous silica nanoparticles are promising as a mucoadhesive and sustained drug delivery system for superficial bladder cancer therapy."
For more information on this research see: Functionalized Mesoporous Silica Nanoparticles with Mucoadhesive and Sustained Drug Release Properties for Potential Bladder Cancer Therapy. Langmuir, 2014;30(21):6151-6161. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news journalists report that additional information may be obtained by contacting Q. Zhang, Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, People's Republic of China. Additional authors for this research include K.G. Neoh, L.Q. Xu, S.J. Lu, E.T. Kang, R. Mahendran and E. Chiong (see also Nanoparticles).
Keywords for this news article include: Wuxi, Asia, Cancer, Oncology, Nanotechnology, Emerging Technologies, People's Republic of China
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