New Nanoparticles Findings from Florida Institute of Technology Described (Attaching high charge density metal ions to surfaces and biomolecules. Reaction chemistry of hypodentate cobalt diamine complexes)
By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting from Melbourne, Florida, by NewsRx journalists, research stated, "Hypodentate diamine cobalt(III) pentammine complexes [Co(NH3)5(NH2(CH2)(n)NH3)](ClO4)4 (8: a: n=3; b: n=4; c: n=6; d: n=8) have been synthesized via the reaction of [Co(NH3)5(OTf)](OTf)2 (TfOH=CF3SO3H) with the corresponding diamines. The analogous t-boc protected diamine complexes [Co(NH3)5(NH2(CH2)(n)NHt-boc)](ClO4)3 (7a-d) were prepared in 4-26% yield."
The news correspondents obtained a quote from the research from the Florida Institute of Technology, "Low yields for the formation of 7a-d are due to competing side reactions which also gave [Co(NH3)6](3+). Complexes 7a-d were deprotected using trifluoroacetic acid to give the corresponding hypodentate diamine complexes [Co(NH3)5(NH2(CH2)(n)NH3)](CF3CO2)0.5(ClO4)3.5 (9a-d). HBTU coupling of 8c with N-(t-boc)-L-phenylalanine gave an amino acid functionalized cobalt pentammine complex [Co(NH3)5(NH2(CH2)6NHt-boc)-L-phenylalanine)](ClO4)3 (10). All new complexes were characterized using UV-vis and (1)H NMR spectroscopy, and elemental analysis. Grafting of 8c onto 2.4 mm poly(ethylene-co-acrylic acid) (PEAA) beads was achieved via amide coupling. Complex 8c was coupled to thioctic acid via amide coupling and the resulting cobalt disulfide complex [Co(NH3)5(N-(6-aminohexyl)-5-(1,2-dithiolan-3-yl)pentanamide)](ClO4)3 (11) was attached to 10 nm Au nanoparticles."
According to the news reporters, the research concluded: "The amount of cobalt loading onto PEAA beads and Au nanoparticles was determined using ICP-MS and EDX."
For more information on this research see: Attaching high charge density metal ions to surfaces and biomolecules. Reaction chemistry of hypodentate cobalt diamine complexes. Dalton Transactions, 2013;42(44):15617-24. (Royal Society of Chemistry - www.rsc.org/; Dalton Transactions - pubs.rsc.org/en/journals/journalissues/dt)
Our news journalists report that additional information may be obtained by contacting A.R. Funk, Chemistry Department, Florida Institute of Technology, 150 University Boulevard, Melbourne, FL 32901, United States. Additional authors for this research include E. Goldberg, E.L. Chang, S.A. Trammell and D.A Knight (see also Nanoparticles).
Keywords for this news article include: Cobalt, Florida, Melbourne, Chemicals, Chemistry, United States, Nanotechnology, Transition Elements, Emerging Technologies, North and Central America.
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