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New Intercellular Signaling Peptides and Proteins Findings from University of Toronto Discussed (Multifunctional albumin-MnO? nanoparticles modulate...

July 8, 2014



New Intercellular Signaling Peptides and Proteins Findings from University of Toronto Discussed (Multifunctional albumin-MnO? nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth ...)

By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Intercellular Signaling Peptides and Proteins is now available. According to news originating from Toronto, Canada, by NewsRx correspondents, research stated, "Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor microenvironment (TME). These abnormalities promote tumor aggressiveness, metastasis, and resistance to therapies."

Our news journalists obtained a quote from the research from the University of Toronto, "To date, there is no treatment available for comprehensive modulation of the TME. Approaches so far have been limited to regulating hypoxia, acidosis, or ROS individually, without accounting for their interdependent effects on tumor progression and response to treatments. Hence we have engineered multifunctional and colloidally stable bioinorganic nanoparticles composed of polyelectrolyte-albumin complex and MnO2 nanoparticles (A-MnO2 NPs) and utilized the reactivity of MnO2 toward peroxides for regulation of the TME with simultaneous oxygen generation and pH increase. In vitro studies showed that these NPs can generate oxygen by reacting with H2O2 produced by cancer cells under hypoxic conditions. A-MnO2 NPs simultaneously increased tumor oxygenation by 45% while increasing tumor pH from pH 6.7 to pH 7.2 by reacting with endogenous H2O2 produced within the tumor in a murine breast tumor model. Intratumoral treatment with NPs also led to the downregulation of two major regulators in tumor progression and aggressiveness, that is, hypoxia-inducible factor-1 alpha and vascular endothelial growth factor in the tumor. Combination treatment of the tumors with NPs and ionizing radiation significantly inhibited breast tumor growth, increased DNA double strand breaks and cancer cell death as compared to radiation therapy alone."

According to the news editors, the research concluded: "These results suggest great potential of A-MnO2 NPs for modulation of the TME and enhancement of radiation response in the treatment of cancer."

For more information on this research see: Multifunctional albumin-MnO? nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response. Acs Nano, 2014;8(4):3202-12. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

The news correspondents report that additional information may be obtained from P. Prasad, Dept. of Pharmaceutical Sciences, Leslie L Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada. Additional authors for this research include C.R. Gordijo, A.Z. Abbasi, A. Maeda, A. Ip, A.M. Rauth, R.S. DaCosta and X.Y Wu (see also Intercellular Signaling Peptides and Proteins).

Keywords for this news article include: Canada, Cancer, Toronto, Ontario, Oncology, North and Central America, Endothelial Growth Factors, Intercellular Signaling Peptides and Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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