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New Findings Reported from University of Connecticut Describe Advances in Vaccines (Effectiveness of a novel immunogenic nanoparticle platform for...

July 9, 2014



New Findings Reported from University of Connecticut Describe Advances in Vaccines (Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice)

By a News Reporter-Staff News Editor at Vaccine Weekly -- Investigators discuss new findings in Immunization. According to news originating from Storrs, Connecticut, by NewsRx correspondents, research stated, "We created and produced a novel self-assembling nanoparticle platform for delivery of peptide epitopes that induces CD8(+) and CD4(+)T cells that are protective against Toxoplasma gondii infection. These selfassembling polypeptide nanoparticles (SAPNs) are composed of linear peptide (LP) monomers which contain two coiled-coil oligomerization domains, the dense granule 7 (GRA7(20-28) LPQFATAAT) peptide and a universal CD4(+)T cell epitope (derived from PADRE)."

Our news journalists obtained a quote from the research from the University of Connecticut, "Purified LPs assemble into nanoparticles with icosahedral symmetry, similar to the capsids of small viruses. These particles were evaluated for their efficacy in eliciting IFN-gamma by splenocytes of HLA-B(*)0702 transgenic mice and for their ability to protect against subsequent T. gondii challenge."

According to the news editors, the research concluded: "This work demonstrates the feasibility of using this platform approach with a CD8(+) epitope that binds HLA-B7 and tests the biological activity of potentially protective peptides restricted by human major histocompatibility complex (HLA) class I molecules in HLA transgenic mice."

For more information on this research see: Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice. Vaccine, 2014;32(26):3243-3248. Vaccine can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Vaccine - www.journals.elsevier.com/vaccine)

The news correspondents report that additional information may be obtained from K. El Bissati, University of Connecticut, Dept. of Mol & Cell Biol, Storrs, CT 06269, United States. Additional authors for this research include Y. Zhou, D. Dasgupta, D. Cobb, J.P. Dubey, P. Burkhard, D.E. Lanar and R. McLeod (see also Immunization).

Keywords for this news article include: Storrs, Vaccines, Connecticut, Immunization, Nanoparticle, United States, Nanotechnology, Biological Products, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Vaccine Weekly


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