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New Findings on Experimental Autoimmune Uveoretinitis Described by Investigators at National Defense Medical College (Evaluation of mouse...

July 11, 2014



New Findings on Experimental Autoimmune Uveoretinitis Described by Investigators at National Defense Medical College (Evaluation of mouse experimental autoimmune uveoretinitis by spectral domain optical coherence tomography)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Autoimmune Diseases and Disorders have been published. According to news reporting originating from Tokorozawa, Japan, by NewsRx correspondents, research stated, "To evaluate the efficacy of spectral domain optical coherence tomography (SD-OCT) in monitoring the development of mouse experimental autoimmune uveoretinitis (EAU) as an animal model of endogenous uveitis, and to develop an OCT-based grading system for EAU severity. C57BL/6 mice were immunised with human interphotoreceptor retinoid-binding protein (amino acid sequence 1-20) peptide and complete Freund's adjuvant to induce EAU."

Our news editors obtained a quote from the research from National Defense Medical College, "The development of EAU was monitored by SD-OCT serially throughout the disease course, and the images were graded from 1 to 4 and compared with the clinical and histopathological grades. SD-OCT images depicted retinal lamella structures including the inner segment/outer segment (IS/OS) line in normal mice. Retinal structural changes were observed on SD-OCT images in mice that developed EAU clinically scored as grade 1 or higher, which precisely corresponded to the pathological findings. The SD-OCT images of EAU were graded as follows: grade 1, a few infiltrating cells in the vitreous and retina; grade 2, increased vitreous cells, retinal vasculitis, and granulomatous lesion; grade 3, cell infiltration into the whole retina, disappearance of IS/OS line, and destruction of the retinal layer structure; and grade 4, disappearance of the outer retina. The SD-OCT grade of EAU based on these criteria correlated significantly with both the clinical grade (R-2=0.282, p

According to the news editors, the research concluded: "The SD-OCT scoring system we developed accurately reflects clinical and histopathological changes."

For more information on this research see: Evaluation of mouse experimental autoimmune uveoretinitis by spectral domain optical coherence tomography. British Journal of Ophthalmology, 2014;98(6):808-812. British Journal of Ophthalmology can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England. (BMJ Publishing Group - group.bmj.com/; British Journal of Ophthalmology - bjo.bmj.com/)

The news editors report that additional information may be obtained by contacting K. Harimoto, National Defense Medical College, Dept. of Dev Anat & Regenerat Biol, Tokorozawa, Saitama 3598513, Japan. Additional authors for this research include M. Ito, Y. Karasawa, Y. Sakurai and M. Takeuchi (see also Autoimmune Diseases and Disorders).

Keywords for this news article include: Asia, Japan, Tokorozawa, Imaging Technology, Optical Coherence Tomography, Autoimmune Diseases and Disorders, Experimental Autoimmune Uveoretinitis

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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