New Findings from Beijing Normal University in the Area of Hypertension Reported (Spectroscopic investigations of the interaction of the anti?hypertension drug valsartan with human serum albumin)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Cardiovascular Diseases and Conditions have been published. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "The aim of the present study was to investigate the interaction between valsartan, an anti-hypertension drug, and human serum albumin (HSA) using spectroscopic techniques, including fluorescence, ultraviolet-visible absorption, synchronous fluorescence and circular dichroism (CD). The results demonstrated that valsartan and HSA form a complex and that a static quenching mechanism occurs."
Our news journalists obtained a quote from the research from Beijing Normal University, "In addition, the binding constant and the number of binding sites for valsartan on HSA were analyzed. Hydrophobic interactions and hydrogen bonds were the predominant forces in the association reaction based on thermodynamic parameters. The distance between the donor (HSA) and the acceptor (valsartan) was 1.994 nm as derived from Forster's theory. Alterations in the secondary structure of HSA in the presence of valsartan were assessed using synchronous fluorescence and CD."
According to the news editors, the research concluded: "This study provides an enhanced understanding of the pharmacodynamic effects of valsartan on the physiologically important protein HSA."
For more information on this research see: Spectroscopic investigations of the interaction of the anti?hypertension drug valsartan with human serum albumin. Molecular Medicine Reports, 2014;9(6):2191-6 (see also Cardiovascular Diseases and Conditions).
Our news journalists report that additional information may be obtained by contacting J. Jing, Dept. of Bioorganic and Biological Chemistry, Beijing Key Lab, Beijing Normal University, Beijing 100875, People's Republic of China. Additional authors for this research include X. Qu, Z. Tu, C. Zheng and Z. Zheng.
Keywords for this news article include: Asia, Beijing, Therapy, Hypertension, Serum Albumin, Blood Proteins, Acute Phase Proteins, People's Republic of China, Cardiovascular Diseases and Conditions.
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