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New DNA Research Study Findings Recently Were Reported by Researchers at University of California (A simple colorimetric DNA detection by...

July 8, 2014



New DNA Research Study Findings Recently Were Reported by Researchers at University of California (A simple colorimetric DNA detection by target-induced hybridization chain reaction for isothermal signal amplification)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on DNA Research. According to news reporting originating in Riverside, California, by NewsRx journalists, research stated, "A novel DNA detection method is presented based on a gold nanoparticle (AuNP) colorimetric assay and hybridization chain reaction (HCR). In this method, target DNA hybridized with probe DNA modified on AuNP, and triggered HCR."

The news reporters obtained a quote from the research from the University of California, "The resulting HCR products with a large number of negative charges significantly enhanced the stability of AuNPs, inhibiting aggregation of AuNPs at an elevated salt concentration. The approach was highly sensitive and selective. Using this enzyme-free and isothermal signal amplification method, we were able to detect target DNA at concentrations as low as 0.5 nM with the naked eye."

According to the news reporters, the research concluded: "Our method also has great potential for detecting other analytes, such as metal ions, proteins, and small molecules, if the target analytes could make HCR products attach to AuNPs."

For more information on this research see: A simple colorimetric DNA detection by target-induced hybridization chain reaction for isothermal signal amplification. Analytical Biochemistry, 2014;457():19-23. Analytical Biochemistry can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Analytical Biochemistry - www.elsevier.com/wps/product/cws_home/622781)

Our news correspondents report that additional information may be obtained by contacting C.P. Ma, University of California, Dept. of Chem & Environm Engn, Riverside, CA 92521, United States. Additional authors for this research include W.S. Wang, A. Mulchandani and C. Shi (see also DNA Research).

Keywords for this news article include: Riverside, California, Proteomics, DNA Research, United States, DNA Detection, Deoxyribonucleic Acid, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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