By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Biosensing have been published. According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "A Dynabeads-labeled magnetic immunoassay (MIA) has been developed by using an integrated giant magnetoimpedance (GMI) biosensor for the detection of alpha-fetoprotein (AFP). The GMI biosensor (Cr/Cu/NiFe/Cu/NiFe/Al2O3/Cr/Au films) integrated magnetic sensing elements and a biomolecular immunoplatform."
Our news editors obtained a quote from the research from Shanghai JiaoTong University, "Au film was modified with 11-Mercaptoundecanoic acid (11-MUA) for the immobilization of AFP monoclonal antibody. Double antibody sandwich immunoassay was used to specifically capture and label AFP antigen. Functionalized Dynabeads were conjugated to AFP antigen by streptavidin-biotin binding assay. GMI responses were measured for sensitive detection of AFP from 1 to 10ng/ml. Our results revealed that the presence of AFP on the biosensor improved the GMI effect owing to the induced magnetic dipole of superparamagnetic Dynabeads, and the GMI ratio was greatly increased at high frequency. Specificity of MIA was tested through the use of 1% bovine serum albumin (BSA). The underlying biophysical mechanisms responsible for the enhanced GMI effect in the detection of AFP were discussed."
According to the news editors, the research concluded: "This work provides a complex lab-on-chip MIA for the detection of biomarker, which may open up a new way for the development of GMI-based MIA in clinical trials."
For more information on this research see: An integrated giant magnetoimpedance biosensor for detection of biomarker. Biosensors & Bioelectronics, 2014;58():338-44. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
The news editors report that additional information may be obtained by contacting T. Wang, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Research Institute of Micro, Nano Science & Technology, Shanghai JiaoTong University, Dong chuan Road 800, Shanghai 200240, People's Republic of China. Additional authors for this research include Z. Yang, C. Lei, J. Lei and Y. Zhou (see also Biosensing).
Keywords for this news article include: Asia, Shanghai, Biosensing, Bioengineering, Bionanotechnology, Nanobiotechnology, People's Republic of China.
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