Both of the breakthroughs are detailed in the
"Our work establishes that lncRNAs in yeast can encode proteins, and we provide evidence that this is probably true also in mammals, including humans," Baker said. "Our investigation has expanded our knowledge of the genetic coding potential of already well-characterized genomes."
Collaborating with researchers including
Previously, lncRNAs were thought to lack the information and capacity to encode for proteins, distinguishing them from the messenger RNAs that are expressed from known genes and act primarily as templates for the synthesis of proteins. Yet this team demonstrated that a subset of these lncRNAs is engaged by the translation machinery and can function to produce protein products.
In the future, Baker and fellow investigators will continue to look for novel RNA transcripts and also search for a function for these lncRNAs and their protein products in cells.
"Discovery of more transcripts equates to the discovery of new and novel genes," Baker said. "The significance of this work is that we have discovered evidence for the expression of previously undiscovered genes. Knowing that genes are expressed is the very first step in figuring out what they do in normal cellular function or in dysfunction and disease."
Keywords for this news article include: Genetics, Amino Acids, Peptides and Proteins,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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