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Investigators from University of Toronto Have Reported New Data on Proinsulin (Signal transduction meets vesicle traffic: the software and hardware...

July 8, 2014



Investigators from University of Toronto Have Reported New Data on Proinsulin (Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation)

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Peptide Proteins is now available. According to news reporting originating from Toronto, Canada, by NewsRx correspondents, research stated, "Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma membrane. This phenomenon, also central to adipocyte biology, has been the subject of intense and productive research for decades."

Our news editors obtained a quote from the research from the University of Toronto, "We focus on muscle cell studies scrutinizing insulin signals and vesicle traffic in a spatiotemporal manner. Using the analogy of an integrated circuit to approach the intersection between signal transduction and vesicle mobilization, we identify signaling relays ('software') that engage structural/mechanical elements ('hardware') to enact the rapid mobilization and incorporation of GLUT4 into the cell surface. We emphasize how insulin signal transduction switches from tyrosine through lipid and serine phosphorylation down to activation of small G proteins of the Rab and Rho families, describe key negative regulation step of Rab GTPases through the GTPase-activating protein activity of the Akt substrate of 160 kDa (AS160), and focus on the mechanical effectors engaged by Rabs 8A and 10 (the molecular motor myosin Va), and the Rho GTPase Rac1 (actin filament branching and severing through Arp2/3 and cofilin)."

According to the news editors, the research concluded: "Finally, we illustrate how actin filaments interact with myosin 1c and alpha-Actinin4 to promote vesicle tethering as preamble to fusion with the membrane."

For more information on this research see: Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. American Journal of Physiology-Cell Physiology, 2014;306(10):C879-C886. American Journal of Physiology-Cell Physiology can be contacted at: Amer Physiological Soc, 9650 Rockville Pike, Bethesda, MD 20814, USA (see also Peptide Proteins).

The news editors report that additional information may be obtained by contacting A. Klip, University of Toronto, Dept. of Biochem, Toronto, ON M5S 1A1, Canada. Additional authors for this research include Y. Sun, T.T. Chiu and K.P. Foley.

Keywords for this news article include: Canada, Toronto, Ontario, Software, Proinsulin, Peptide Hormones, Peptide Proteins, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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