Investigators at Oregon State University Detail Findings in Colloids and Interface Science (Concentration effects on peptide elution from pendant PEO layers)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Colloids and Interface Science have been published. According to news reporting out of Corvallis, Oregon, by NewsRx editors, research stated, "In earlier work, we have provided direction for development of responsive drug delivery systems based on modulation of structure and amphiphilicity of bioactive peptides entrapped within pendant polyethylene oxide (PEO) brush layers. Amphiphilicity promotes retention of the peptides within the hydrophobic inner region of the PEO brush layer."
Our news journalists obtained a quote from the research from Oregon State University, "In this work, we describe the effects of peptide surface density on the conformational changes caused by peptide-peptide interactions, and show that this phenomenon substantially affects the rate and extent of peptide elution from PEO brush layers. Three cationic peptides were used in this study: the arginine-rich amphiphilic peptide WLBU2, the chemically identical but scrambled peptide S-WLBU2, and the non-amphiphilic homopolymer poly-L-arginine (PLR). Circular dichroism (CD) was used to evaluate surface density effects on the structure of these peptides at uncoated (hydrophobic) and PEO-coated silica nanoparticles. UV spectroscopy and a quartz crystal microbalance with dissipation monitoring (QCM-D) were used to quantify changes in the extent of peptide elution caused by those conformational changes. For amphiphilic peptides at sufficiently high surface density, peptide-peptide interactions result in conformational changes which compromise their resistance to elution. In contrast, elution of a non-amphiphilic peptide is substantially independent of its surface density, presumably due to the absence of peptide-peptide interactions."
According to the news editors, the research concluded: "The results presented here provide a strategy to control the rate and extent of release of bioactive peptides from PEO layers, based on modulation of their amphiphilicity and surface density."
For more information on this research see: Concentration effects on peptide elution from pendant PEO layers. Colloids and Surfaces B-Biointerfaces, 2014;118():210-217. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Colloids and Interface Science).
Our news journalists report that additional information may be obtained by contacting X.M. Wu, Oregon State University, Sch Chem Biol & Environm Engn, Corvallis, OR 97331, United States. Additional authors for this research include M.P. Ryder, J. McGuire and K.F. Schilke.
Keywords for this news article include: Oregon, Corvallis, United States, North and Central America, Colloids and Interface Science
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