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Investigators at Faculty of Medicine Report New Data on Stem Cells (Concise review: reprogramming strategies for cardiovascular regenerative...

July 9, 2014



Investigators at Faculty of Medicine Report New Data on Stem Cells (Concise review: reprogramming strategies for cardiovascular regenerative medicine: from induced pluripotent stem cells to direct reprogramming)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Stem Cell Research. According to news reporting originating in Haifa, Israel, by NewsRx journalists, research stated, "Myocardial cell-replacement therapies are emerging as novel therapeutic paradigms for myocardial repair but are hampered by the lack of sources of autologous human cardiomyocytes. The recent advances in stem cell biology and in transcription factor-based reprogramming strategies may provide exciting solutions to this problem."

The news reporters obtained a quote from the research from the Faculty of Medicine, "In the current review, we describe the different reprogramming strategies that can give rise to cardiomyocytes for regenerative medicine purposes. Initially, we describe induced pluripotent stem cell technology, a method by which adult somatic cells can be reprogrammed to yield pluripotent stem cells that could later be coaxed ex vivo to differentiate into cardiomyocytes. The generated induced pluripotent stem cell-derived cardiomyocytes could then be used for myocardial cell transplantation and tissue engineering strategies. We also describe the more recent direct reprogramming approaches that aim to directly convert the phenotype of one mature cell type (fibroblast) to another (cardiomyocyte) without going through a pluripotent intermediate cell type."

According to the news reporters, the research concluded: "The advantages and shortcomings of each strategy for cardiac regeneration are discussed, along with the hurdles that need to be overcome on the road to clinical translation."

For more information on this research see: Concise review: reprogramming strategies for cardiovascular regenerative medicine: from induced pluripotent stem cells to direct reprogramming. Stem Cells Translational Medicine, 2014;3(4):448-57 (see also Stem Cell Research).

Our news correspondents report that additional information may be obtained by contacting I. Budniatzky, Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine and Cardiology Department, Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.

Keywords for this news article include: Asia, Tissue Engineering, Haifa, Israel, Cardiology, Cardiomyocyte, Cardiovascular, Adult Stem Cells, Stem Cell Research, Induced Pluripotent Stem Cells.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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