Findings on Epithelial Cells Discussed by
Our news editors obtained a quote from the research, "To better understand this relationship, the present study examined the role of WC-Co particle size and internalization on toxicity using lung epithelial cells. We demonstrated that nano-and micro-WC-Co particles exerted toxicity in a dose-and time-dependent manner and that nano-WC-Co particles caused significantly greater toxicity at lower concentrations and shorter exposure times compared to micro-WC-Co particles. WC-Co particles in the nano-size range (not micron-sized) were internalized by lung epithelial cells, which suggested that internalization may play a key role in the enhanced toxicity of nano-WC-Co particles over micro-WC-Co particles. Further exploration of the internalization process indicated that there may be multiple mechanisms involved in WC-Co internalization such as actin and microtubule based cytoskeletal rearrangements."
According to the news editors, the research concluded: "These findings support our hypothesis that WC-Co particle internalization contributes to cellular toxicity and suggest that therapeutic treatments inhibiting particle internalization may serve as prophylactic approaches for those at risk of WC-Co particle exposure."
For more information on this research see: Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro. Toxicology and Applied Pharmacology, 2014;278(1):1-8. Toxicology and Applied Pharmacology can be contacted at: Academic Press Inc Elsevier Science,
The news editors report that additional information may be obtained by contacting
Keywords for this news article include: Cobalt, Chemicals, Chemistry,
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