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Findings from University of Wisconsin Provide New Insights into Molecular Imaging (Design and Applications of Bispecific Heterodimers: Molecular...

July 9, 2014



Findings from University of Wisconsin Provide New Insights into Molecular Imaging (Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Molecular Imaging. According to news reporting out of Madison, Wisconsin, by NewsRx editors, research stated, "Ligand-based molecular imaging probes have been designed with high affinity and specificity for monitoring biological process and responses. Single-target recognition by traditional probes can limit their applicability for disease detection and therapy because synergistic action between disease mediators and different receptors is often involved in disease progression."

Our news journalists obtained a quote from the research from the University of Wisconsin, "Consequently, probes that can recognize multiple targets should demonstrate higher targeting efficacy and specificity than their monospecific peers. This concept has been validated by multiple bispecific heterodimer-based imaging probes that have demonstrated promising results in several animal models. This review summarizes the design strategies for bispecific peptide- and antibody-based heterodimers and their applications in molecular targeting and imaging."

According to the news editors, the research concluded: "The design and application of bispecific heterodimer-conjugated nanomaterials are also discussed."

For more information on this research see: Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond. Molecular Pharmaceutics, 2014;11(6):1750-1761. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news journalists report that additional information may be obtained by contacting H.M. Luo, University of Wisconsin, Carbone Canc Center, Madison, WI 53705, United States. Additional authors for this research include H. Hong, S.P. Yang and W.B. Cai (see also Molecular Imaging).

Keywords for this news article include: Madison, Wisconsin, United States, Nanotechnology, Molecular Imaging, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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