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Findings from University Hospital Broaden Understanding of Mononuclear Phagocyte System (Role of metal oxide nanoparticles in histopathological...

July 11, 2014



Findings from University Hospital Broaden Understanding of Mononuclear Phagocyte System (Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Immunology have been published. According to news reporting from Creteil, France, by NewsRx journalists, research stated, "Although major concerns exist regarding the potential consequences of human exposure to nanoparticles (NP), no human toxicological data is currently available. To address this issue, we took welders, who present various adverse respiratory outcomes, as a model population of occupational exposure to NP."

The news correspondents obtained a quote from the research from University Hospital, "The aim of this study was to evaluate if welding fume-issued NP could be responsible, at least partially, in the lung alterations observed in welders. A combination of imaging and material science techniques including ((scanning) transmission electron microscopy ((S) TEM), energy dispersive X-ray (EDX), and X-ray microfluorescence (mu XRF)), was used to characterize NP content in lung tissue from 21 welders and 21 matched control patients. Representative NP were synthesized, and their effects on macrophage inflammatory secretome and migration were evaluated, together with the effect of this macrophage inflammatory secretome on human lung primary fibroblasts differentiation. Welding-related NP (Fe, Mn, Cr oxides essentially) were identified in lung tissue sections from welders, in macrophages present in the alveolar lumen and in fibrous regions. In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1 beta, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber). There was no effect of NP-exposed macrophage secretome on human primary lung fibroblasts differentiation. Altogether, the data reported here strongly suggest that welding-related NP could be responsible, at least in part, for the pulmonary inflammation observed in welders."

According to the news reporters, the research concluded: "These results provide therefore the first evidence of a link between human exposure to NP and long-term pulmonary effects."

For more information on this research see: Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders. Particle and Fibre Toxicology, 2014;11():1-13. Particle and Fibre Toxicology can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Particle and Fibre Toxicology - www.particleandfibretoxicology.com)

Our news journalists report that additional information may be obtained by contacting P. Andujar, CHU Henri Mondor, Serv Explorat Fonct Resp, F-94000 Creteil, France. Additional authors for this research include A. Simon-Deckers, F. Galateau-Salle, B. Fayard, G. Beaune, B. Clin, M.A. Billon-Galland, O. Durupthy, J.C. Pairon, J. Doucet, J. Boczkowski and S. Lanone (see also Immunology).

Keywords for this news article include: France, Europe, Creteil, Immunology, Macrophages, Nanoparticle, Nanotechnology, Emerging Technologies, Mononuclear Phagocyte System

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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