Findings from United States Department of Agriculture Provide New Insights into Brucellosis (Recent developments in livestock and wildlife brucellosis vaccination)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Gram-Negative Bacterial Infections. According to news reporting originating from Ames, Iowa, by NewsRx editors, the research stated, "Live attenuated brucellosis vaccines have been available for protecting domestic livestock against Brucella melitensis and B. abortus for more than 60 years. Current vaccines are effective in preventing abortion and transmission of brucellosis, but poor at preventing infection or seroconversion."
Our news editors obtained a quote from the research from the United States Department of Agriculture, "In addition, they can induce abortions in pregnant animals and are infectious to humans. It can be argued that current vaccines were developed empirically in that the immunological mechanism(s) of action were not determined. Current knowledge suggests that both the innate and adaptive immune responses contribute to immunity against intracellular pathogens and that binding of pathogen structures onto pattern recognition receptors (PRRs) is crucial to the development of adaptive immunity. The phagosome appears to be vital for the presentation of antigens to T-cell subtypes that provide protective immunity to intracellular pathogens. The observation that killed bacteria or subunit vaccines do not appear to fully stimulate PRRs, or mimic Brucella trafficking through phagosomes, may explain their inability to induce immunity that equals the protection provided by live attenuated vaccines. Brucella appears to have multiple mechanisms that subvert innate and adaptive immunity and prevent or minimise immunological responses. New technologies, such as DNA vaccines and nanoparticles, may be capable of delivering Brucella antigens in a way that induces protective immunity in domestic livestock or wildlife reservoirs of brucellosis. Because of the reemergence of brucellosis worldwide, with an increasing incidence of human infection, there is a great need for improved brucellosis vaccines."
According to the news editors, the research concluded: "The greatest need is for new or improved vaccines against B. melitensis and B. suis."
For more information on this research see: Recent developments in livestock and wildlife brucellosis vaccination. Revue Scientifique Et Technique-Office International Des Epizooties, 2013;32(1):207-217. Revue Scientifique Et Technique-Office International Des Epizooties can be contacted at: Office Int Epizooties, 12 Rue De Prony, 75017 Paris, France (see also Gram-Negative Bacterial Infections).
The news editors report that additional information may be obtained by contacting S.C. Olsen, Dept. of Agriculture ARS, Bacterial Dis Livestock Res Unit, Natl Anim Dis Center, Ames, IA 50010, United States.
Keywords for this news article include: Ames, Iowa, Livestock, Agriculture, Brucellosis, Brucellaceae, United States, Alphaproteobacteria, North and Central America, Gram-Negative Bacterial Infections, Gram-Negative Aerobic Rods and Cocci
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