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Findings from Sichuan University Broaden Understanding of Cancer Therapy (Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug...

July 9, 2014



Findings from Sichuan University Broaden Understanding of Cancer Therapy (Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Oncology have been published. According to news reporting originating in Chengdu, People's Republic of China, by NewsRx journalists, research stated, "Alpha-Cyclodextrin/poly(ethylene glycol) (alpha-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate (MTX) was loaded in the nanoparticles."

The news reporters obtained a quote from the research from Sichuan University, "The interaction between MTX and polyrotaxane was investigated. The formation, morphology, drug release and in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles were studied. The results show that the ATFX could be efficiently absorbed on the nanoparticles, and hydrogen bonds were formed between MTX and alpha-CDs. The typical channel-type stacking assembly style of polyrotaxane nanoparticles was changed after MTX was loaded. The mean diameter of drug loaded polyrotaxane nanoparticles were around 200 nm and the drug loading content was as high as about 20%. Drug release profiles show that most of the loaded MTX was released within 8 hours and the cumulated release rate was as high as 98%. The blank polyrotaxane nanoparticles were nontoxicity to cells."

According to the news reporters, the research concluded: "The in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles was higher than that of free MTX."

For more information on this research see: Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery. Nano-Micro Letters, 2014;6(2):108-115. Nano-Micro Letters can be contacted at: Open Access House Science & Technology, 2840 N Boxwood Dr, Fayette, AR 72703, USA (see also Oncology).

Our news correspondents report that additional information may be obtained by contacting L.G. Zhang, Sichuan University, Natl Engn Res Center Biomat, Chengdu 610064, People's Republic of China. Additional authors for this research include T. Su, B. He and Z.W. Gu.

Keywords for this news article include: Asia, Chengdu, Therapy, Oncology, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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