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Findings from CREST Research Project Broaden Understanding of Enzymes and Coenzymes (Installing logic-gate responses to a variety of biological...

July 8, 2014



Findings from CREST Research Project Broaden Understanding of Enzymes and Coenzymes (Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel-enzyme hybrids)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news reporting originating from Tokyo, Japan, by NewsRx correspondents, research stated, "Soft materials that exhibit stimuli-responsive behaviour under aqueous conditions (such as supramolecular hydrogels composed of self-assembled nanofibres) have many potential biological applications. However, designing a macroscopic response to structurally complex biochemical stimuli in these materials still remains a challenge."

Our news editors obtained a quote from the research from CREST Research Project, "Here we show that redoxresponsive peptide-based hydrogels have the ability to encapsulate enzymes and still retain their activities. Moreover, cooperative coupling of enzymatic reactions with the gel response enables us to construct unique stimuli-responsive soft materials capable of sensing a variety of disease-related biomarkers. The programmable gel-sol response (even to biological samples) is visible to the naked eye. Furthermore, we built Boolean logic gates (OR and AND) into the hydrogel-enzyme hybrid materials, which were able to sense simultaneously plural specific biochemicals and execute a controlled drug release in accordance with the logic operation."

According to the news editors, the research concluded: "The intelligent soft materials that we have developed may prove valuable in future medical diagnostics or treatments."

For more information on this research see: Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel-enzyme hybrids. Nature Chemistry, 2014;6(6):511-518. Nature Chemistry can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Nature Chemistry - www.nature.com/nchem/)

The news editors report that additional information may be obtained by contacting M. Ikeda, Japan Sci & Technol Agcy JST, CREST, Chiyoda Ku, Tokyo 1020075, Japan. Additional authors for this research include T. Tanida, T. Yoshii, K. Kurotani, S. Onogi, K. Urayama and I. Hamachi (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, Tokyo, Japan, Alcohols, Hydrogel, Nanotechnology, Supramolecular, Organic Chemicals, Polyethylene Glycols, Emerging Technologies, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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