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Data on Medicinal Chemistry Reported by Researchers at Singapore National University (Delivery of Therapeutics and Molecules Using Self-Assembled...

July 11, 2014



Data on Medicinal Chemistry Reported by Researchers at Singapore National University (Delivery of Therapeutics and Molecules Using Self-Assembled Peptides)

By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Health and Medicine is the subject of a report. According to news reporting out of Singapore, Singapore, by NewsRx editors, research stated, "The use of nanobiotechnology in the formulation of drug carriers has been gaining popularity in recent years. Peptide self-assembly technology is a particularly attractive option due to its simplicity and programmability."

Our news journalists obtained a quote from the research from Singapore National University, "Self-assembling peptide amphiphiles are surfactant-like molecules that are capable of spontaneous organization into a variety of nanostructures. The structural and functional features of these nanostructures can be designed through alterations to the peptide sequence. With a keen understanding of the supramolecular principles governing the non-covalent interactions involved, drug loading strategies can be customised. Hydrophobic drugs can be hidden within the core via aromatic interactions while gene-based therapeutics can be complexed with a cationic region of lysine residues. This review article focuses on the application of self-assembling peptide amphiphiles to drug delivery in the area of anti-cancer therapeutics, protein-and peptide-based therapeutics and nucleic acid-based therapeutics."

According to the news editors, the research concluded: "Specific examples are used to discuss the various systems available and emphasis is given to the encapsulation and release mechanism."

For more information on this research see: Delivery of Therapeutics and Molecules Using Self-Assembled Peptides. Current Medicinal Chemistry, 2014;21(22):2469-2479. Current Medicinal Chemistry can be contacted at: Bentham Science Publ Ltd, Executive Ste Y-2, PO Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates. (Bentham Science Publishers - www.benthamscience.com; Current Medicinal Chemistry - www.benthamscience.com/cmc/index.htm)

Our news journalists report that additional information may be obtained by contacting S. Sundar, Singapore National University, Dept. of Chem & Biomol Engn, Singapore 119077, Singapore. Additional authors for this research include Y. Chen and Y.W. Tong (see also Health and Medicine).

Keywords for this news article include: Asia, Health and Medicine

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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