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Data on Drug Delivery Systems Described by Researchers at Maringa State University (Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for...

July 11, 2014



Data on Drug Delivery Systems Described by Researchers at Maringa State University (Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for magnetic field-modulated drug delivery)

By a News Reporter-Staff News Editor at Drug Week -- A new study on Drugs and Therapies is now available. According to news reporting originating in Maringa, Brazil, by NewsRx journalists, research stated, "Covalent TiO2-co-pectin microspheres containing Fe3O4 nanoparticles were developed through an ultrasound-induced crosslinking/polymerization reaction between the glycidyl methacrylate from vinyl groups in TiO2 and in pectin zeta-potentials became less negative in the nanostructured microspheres, caused by the presence of both inorganic particles in the negatively charged pectin. The nanostructured pectin microspheres showed an amoxicillin release rate slower than that of pure pectin microspheres."

The news reporters obtained a quote from the research from Maringa State University, "The proposed microspheres were found to be a sustained release system of amoxicillin in the acid medium. Furthermore, the antibiotic release may be modulated by exposition of the microspheres to a remote magnetic field. In practical terms, the nanostructured microspheres could deliver a larger proportion of their initial load to specific site of action. The cytotoxic concentrations for 50% of VERO cells (CC50), calculated as the concentration required to reduce cell viability by 50% after 72 h of incubation, for pectin-only microspheres and nanostructured pectin microspheres were 217.7 +/- 6.5 and 121.5 +/- 4.9 pg mL(-1), respectively."

According to the news reporters, the research concluded: "The obtained CC50 values indicated acceptable cytotoxic levels for an incubation period of 72 h, showing that the pectin microspheres have a great pharmacological potential for uses in biological environments, even after the introduction of both Fe3O4 and TiO2."

For more information on this research see: Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for magnetic field-modulated drug delivery. International Journal of Biological Macromolecules, 2014;67():43-52. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)

Our news correspondents report that additional information may be obtained by contacting E.P. da Silva, Maringa State University, Dept. of Basic Sci Hlth, Grad Program Pharmaceut Sci, BR-87020900 Maringa, Parana, Brazil. Additional authors for this research include D.L.A. Sitta, V.H. Fragal, T.S.P. Cellet, M.R. Mauricio, F.P. Garcia, C.V. Nakamura, M.R. Guilherme, A.F. Rubira and M.H. Kunita (see also Drugs and Therapies).

Keywords for this news article include: Brazil, Maringa, Nanoparticle, South America, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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