News Column

Data from McGill University Provide New Insights into Therapeutics (Delivery validation of an automated modulated electron radiotherapy plan)

July 9, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Therapeutics. According to news reporting from Montreal, Canada, by NewsRx journalists, research stated, "Modulated electron radiation therapy (MERT) represents an active area of interest that offers the potential to improve healthy tissue sparing in treatment of certain cancer cases. Challenges remain however in accurate beamlet dose calculation, plan optimization, collimation method, and delivery accuracy."

The news correspondents obtained a quote from the research from McGill University, "In this work, the authors investigate the accuracy and efficiency of an end-to-end MERT plan and automated delivery method. Treatment planning was initiated on a previously treated whole breast irradiation case including an electron boost. All dose calculations were performed using Monte Carlo methods and beam weights were determined using a research-based treatment planning system capable of inverse optimization. The plan was delivered to radiochromic film placed in a water equivalent phantom for verification, using an automated motorized tertiary collimator. The automated delivery, which covered four electron energies, 196 subfields, and 6183 total MU was completed in 25.8 min, including 6.2 min of beam-on time. The remainder of the delivery time was spent on collimator leaf motion and the automated interfacing with the accelerator in service mode. Comparison of the planned and delivered film dose gave 3%/3mm gamma pass rates of 62.1%, 99.8%, 97.8%, 98.3%, and 98.7% for the 9, 12, 16, and 20 MeV, and combined energy deliveries, respectively. Delivery was also performed with aMapCHECK device and resulted in 3%/3 mm gamma pass rates of 88.8%, 86.1%, 89.4%, and 94.8% for the 9, 12, 16, and 20 MeV energies, respectively."

According to the news reporters, the research concluded: "Results of the authors' study showed that an accurate delivery utilizing an add-on tertiary electron collimator is possible using Monte Carlo calculated plans and inverse optimization, which brings MERT closer to becoming a viable option for physicians in treating superficial malignancies."

For more information on this research see: Delivery validation of an automated modulated electron radiotherapy plan. Medical Physics, 2014;41(6):179-191. Medical Physics can be contacted at: Amer Assoc Physicists Medicine Amer Inst Physics, Ste 1 No 1, 2 Huntington Quadrangle, Melville, NY 11747-4502, USA. (American Association of Physicists in Medicine -; Medical Physics -

Our news journalists report that additional information may be obtained by contacting T. Connell, McGill University, Medical Phys Unit, Montreal, PQ H3G 1A4, Canada. Additional authors for this research include A. Alexander, P. Papaconstadopoulos, M. Serban, S. Devic and J. Seuntjens (see also Therapeutics).

Keywords for this news article include: Quebec, Canada, Montreal, Radiotherapy, Therapeutics, North and Central America

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Source: Biotech Week

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