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University of Aveiro Details Findings in Oligopeptides (Modulation of glutathione and its dependent enzymes in gill cells of Anguilla anguilla...

July 22, 2014



University of Aveiro Details Findings in Oligopeptides (Modulation of glutathione and its dependent enzymes in gill cells of Anguilla anguilla exposed to silica coated iron oxide nanoparticles with or without mercury co-exposure under in vitro ...)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Peptides is the subject of a report. According to news originating from Aveiro, Portugal, by NewsRx correspondents, research stated, "The current study aimed to investigate the modulation of glutathione (GSH) and its dependent enzymes (glutathione reductase, GR; glutathione peroxidase, GPx; glutathione sulfotransferase, GST) from 0 to 72 h in the gill cells of Anguilla anguilla under in vitro condition exposed to silica coated iron oxide nanoparticles functionalized with dithiocarbamate (Fe?O?@SiO?/SiDTC, hereafter called 'IONPs'; 100 nm; 2.5 mgL(-1)) with or without mercury (Hg) coexposure. Significantly decreased TGSH content under IONP alone exposure from 0 to 72 h indicated increased utilization of the TGSH in response to IONP stress."

Our news journalists obtained a quote from the research from the University of Aveiro, "Significant increases in the activity of GR, GPx and GST were depicted when exposed to IONP alone. Lipid peroxidation (LPO), a membrane damage trait also significantly increased under IONP alone exposure indicating the efficient role of antioxidant induction abolishing the IONP-mediated enhanced reactive oxygen species. Under Hg exposure, gill cells displayed significantly increased activity of the studied enzymes (GR, GPx and GST) and LPO which was accompanied by significantly decreased TGSH content. Concomitant (IONPs+Hg) exposure displayed a synergistic response to that of individual responses of either IOPN or Hg which was evident by significant increases in GR, GPx, GST and LPO."

According to the news editors, the research concluded: "Overall, our findings revealed a fine tuning among the GSH and its dependent enzyme modulation under IONP, Hg and its concomitant (IONPs+Hg) exposure in A. anguilla gill cells under in vitro condition."

For more information on this research see: Modulation of glutathione and its dependent enzymes in gill cells of Anguilla anguilla exposed to silica coated iron oxide nanoparticles with or without mercury co-exposure under in vitro condition. Comparative Biochemistry and Physiology - Part C, 2014;162():7-14. Comparative Biochemistry and Physiology - Part C can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Comparative Biochemistry and Physiology - Part C - www.elsevier.com/wps/product/cws_home/525466)

The news correspondents report that additional information may be obtained from K. Srikanth, CESAM-Centre for Environmental and Marine Studies & Dept. of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Additional authors for this research include I. Ahmad, J.V. Rao, T. Trindade, A.C. Duarte and E. Pereira (see also Peptides).

The publisher's contact information for the journal Comparative Biochemistry and Physiology - Part C is: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA.

Keywords for this news article include: Aveiro, Europe, Portugal, Glutathione, Nanoparticle, Oligopeptides, Nanotechnology, Emerging Technologies, Enzymes and Coenzymes.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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