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Study Results from University of Tubingen Broaden Understanding of Melanomas (Raman spectroscopy as an analytical tool for melanoma research)

July 23, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Melanomas are presented in a new report. According to news reporting originating from Tubingen, Germany, by NewsRx correspondents, research stated, "Raman spectroscopy is an optical noninvasive screening technology that generates individual fingerprints of living cells by reflecting their molecular constitution. To discriminate melanoma cells from melanocytes, to identify drug-induced melanoma cell death stages (apoptosis, necrosis, autophagy) and to assess the susceptibility of melanoma cells to anticancer therapy."

Our news editors obtained a quote from the research from the University of Tubingen, "We used Raman spectroscopy on normal and melanoma cells, and on wild-type (WT) and mutant melanoma cells, to investigate whether the technique could distinguish between different types of cells, identify mutations and evaluate response to anticancer therapy. Using the multivariate principal component analysis of the Raman spectra, melanocytes could be distinguished from melanoma cells, and WT melanoma cells could be distinguished from melanoma cells with BRAF or NRAS mutations. When we used the apoptosis inducer staurosporine, the necrosis inducer 3-bromopyruvate and the autophagy inducer resveratrol to induce cell death in SKMEL28 melanoma cells, Raman spectroscopy clearly distinguished between these three types of cell death, as confirmed by immunoblotting. Finally, the technique could discriminate between different melanoma cell lines according to their susceptibility to high-dose ascorbate."

According to the news editors, the research concluded: "Raman spectroscopy is a powerful noninvasive tool to distinguish between melanocytes and melanoma cells, to analyze the specific type of cell death in melanoma cells, and to predict the susceptibility of melanoma cells to anticancer drugs."

For more information on this research see: Raman spectroscopy as an analytical tool for melanoma research. Clinical and Experimental Dermatology, 2014;39(5):636-645. Clinical and Experimental Dermatology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Clinical and Experimental Dermatology -

The news editors report that additional information may be obtained by contacting E. Brauchle, University of Tubingen, Dept. of Dermatol, Sect Dermatooncol, D-72076 Tubingen, Germany. Additional authors for this research include S. Noor, E. Holtorf, C. Garbe, K. Schenke-Layland and C. Busch (see also Melanomas).

Keywords for this news article include: Europe, Germany, Therapy, Tubingen, Genetics, Melanomas, Melanocytes

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Source: Biotech Week

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