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Study Findings on Pharmacology and Toxicology Are Outlined in Reports from Uppsala University (Cancer Biology, Toxicology and Alternative Methods...

July 22, 2014

Study Findings on Pharmacology and Toxicology Are Outlined in Reports from Uppsala University (Cancer Biology, Toxicology and Alternative Methods Development Go Hand-in-Hand)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Drugs and Therapies. According to news reporting originating from Uppsala, Sweden, by NewsRx correspondents, research stated, "Toxicological research faces the challenge of integrating knowledge from diverse fields and novel technological developments generally in the biological and medical sciences. We discuss herein the fact that the multiple facets of cancer research, including discovery related to mechanisms, treatment and diagnosis, overlap many up and coming interest areas in toxicology, including the need for improved methods and analysis tools."

Our news editors obtained a quote from the research from Uppsala University, "Common to both disciplines, in vitro and in silico methods serve as alternative investigation routes to animal studies. Knowledge on cancer development helps in understanding the relevance of chemical toxicity studies in cell models, and many bioinformatics-based cancer biomarker discovery tools are also applicable to computational toxicology. Robotics-aided, cell-based, high-throughput screening, microscale immunostaining techniques and gene expression profiling analyses are common tools in cancer research, and when sequentially combined, form a tiered approach to structured safety evaluation of thousands of environmental agents, novel chemicals or engineered nanomaterials. Comprehensive tumour data collections in databases have been translated into clinically useful data, and this concept serves as template for computer-driven evaluation of toxicity data into meaningful results."

According to the news editors, the research concluded: "Future cancer research-inspired knowledge management' of toxicological data will aid the translation of basic discovery results and chemicals- and materials-testing data to information relevant to human health and environmental safety."

For more information on this research see: Cancer Biology, Toxicology and Alternative Methods Development Go Hand-in-Hand. Basic & Clinical Pharmacology & Toxicology, 2014;115(1):50-58. Basic & Clinical Pharmacology & Toxicology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Basic & Clinical Pharmacology & Toxicology -

The news editors report that additional information may be obtained by contacting P. Kohonen, Uppsala University, Dept. of Pharmaceut Biosci, Uppsala, Sweden. Additional authors for this research include R. Ceder, I. Smit, V. Hongisto, G. Myatt, B. Hardy, O. Spjuth and R. Grafstrom (see also Drugs and Therapies).

Keywords for this news article include: Sweden, Europe, Cancer, Uppsala, Oncology, Chemicals, Chemistry, Drugs and Therapies

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Source: Cancer Weekly

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