Study Data from Japan Advanced Institute of Science and Technology Update Understanding of DNA Research (Creation of DNA array structure equipped with heat resistance by ultrafast photocrosslinking)
By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on DNA Research have been presented. According to news reporting originating from Ishikawa, Japan, by NewsRx correspondents, research stated, "The outstanding specificity of the A-T and G-C Watson-Crick hydrogen-bonding interaction allows various DNA nanostructures to be created, which has increased interest in using DNA as a bio- or nano-material. DNA nanostructures have already been used for many applications as well as to create a platform for nanopatterning of a variety of function molecules."
Our news editors obtained a quote from the research from the Japan Advanced Institute of Science and Technology, "However, these structures can be used only at low temperature of Tm value or less in solution because they melt beyond this temperature. This paper reports the creation of a DNA array structure held by photocrosslinking mediated 3-cyanovinylcarbazole (K-CNV) which allows crosslinking by photoirradiation in a few seconds. The thermal stability of DNA nanostructures containing K-CNV were evaluated before and after 366nm UV-exposure by denaturing polyacrylamide gel electrophoresis and the melting curve. When K-CNV was arranged in a suitable position into a 2D DNA array, its photocrosslinked structure was stable under denaturing conditions. The solution-state melting profile of the photocrosslinked DNA array was expanded to > 80 degrees C, which is at least a 40 degrees C increase and showed decreased hyperchromic effect when compared with a non-photocrosslinked structure."
According to the news editors, the research concluded: "The method of creatingDNAstructures equipped with thermal resistance by ultrafast photocrosslinking reaction provides practical DNA nanodevices and enables the stepwise assembly of DNA structures."
For more information on this research see: Creation of DNA array structure equipped with heat resistance by ultrafast photocrosslinking. Journal of Chemical Technology and Biotechnology, 2014;89(7):1086-1090. Journal of Chemical Technology and Biotechnology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Chemical Technology and Biotechnology - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4660)
The news editors report that additional information may be obtained by contacting S. Nakamura, Japan Adv Inst Sci & Technol, Res Center Bioarchitecture, Nomi, Ishikawa 9231292, Japan (see also DNA Research).
Keywords for this news article include: Asia, Japan, Ishikawa, DNA Research, Nanostructural, Nanostructures, Nanotechnology, Emerging Technologies
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